N-acetylglycine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names N-acetylglycine
Structure
CAS No. 543-24-8 Boiling Point (℃) 405.1±28.0 °C at 760 mmHg
Molecular Weight 117.103 Melting Point (℃) 207-209 °C(lit.)
Density 1.2±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C4H7NO3 Flash Point (℃) 198.8±24.0 °C
Solubility 2.7 g/100 mL (15 ºC) Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description N-Acetylglycine is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics.
Target Human Endogenous Metabolite
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Harper MS, et al. Toxicology studies with N-acetylglycine. Food Chem Toxicol. 2010 May;48(5):1321-7.
Synonyms
N-acetyl-Gly
ACETYL-GLYCIN
Aceturic acid
N-Acetylglycine
CH3CONHCH2COOH
Glycine, N-acetyl-
ACETYGLYCINE
acetylaminoacetic acid
Ethanoylaminoethanoic acid
N-Ac-Gly-OH
ACETYL-GLYCINE
ACETOGLYCINE
MFCD00004275
AC-GLYCINE
N-acetyl-glycine
Product Description
Introduction: N-Acetylglycine, also known as Acetyl Glycine or N-Acetyl Aminoethanoic Acid, is a chemical compound derived from glycine, an essential amino acid. It is widely used in various industries, including pharmaceuticals, cosmetics, and food additives. N-Acetylglycine offers several beneficial properties and applications due to its unique chemical structure.

Raw Materials: N-Acetylglycine is produced by the acetylation of glycine using acetic anhydride or acetic acid as the acetylating agent. Glycine, the primary raw material, can be obtained through chemical synthesis or fermentation processes. Acetic anhydride or acetic acid, a common reagent, is used to introduce the acetyl group to the glycine molecule, resulting in N-Acetylglycine.

Production Process: The production of N-Acetylglycine involves the careful combination of glycine and the acetylating agent under controlled reaction conditions. The acetylation reaction is carried out using appropriate catalysts and reaction parameters to ensure a high yield and purity of the product. The resulting N-Acetylglycine is then subjected to purification techniques, such as crystallization or chromatography, to obtain a refined and stable form.

Market Trends: N-Acetylglycine has gained significant attention in various industries due to its multifunctional properties. In the pharmaceutical industry, N-Acetylglycine is utilized in the synthesis of certain drugs and as a potential therapeutic agent for conditions related to neurological disorders and oxidative stress. In the cosmetics industry, it is incorporated into skincare formulations for its moisturizing and skin-conditioning effects. Additionally, N-Acetylglycine finds application as a food additive, providing taste enhancement and serving as a precursor in flavor synthesis.

Amino Acid Status: Glycine, the precursor to N-Acetylglycine, is a non-essential amino acid that plays a vital role in various physiological processes, including protein synthesis, neurotransmission, and detoxification. The acetylation of glycine enhances its stability and bioavailability, allowing for greater utilization in different applications. N-Acetylglycine's incorporation into various products expands the range of benefits and applications associated with glycine.

Conclusion: N-Acetylglycine is a versatile compound derived from glycine, offering a wide range of applications in the pharmaceutical, cosmetics, and food industries. Its production involves the acetylation of glycine under controlled conditions, ensuring consistent product quality. With its multifunctional properties and diverse applications, N-Acetylglycine continues to attract interest from various industries. As research and development in amino acids advance, N-Acetylglycine's potential benefits and applications are expected to expand, contributing to the advancement of pharmaceuticals, cosmetics, and food formulations.

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