N-acetyl-L-valine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Acetylvaline
Structure
CAS No. 96-81-1 Boiling Point (℃) 362.2±25.0 °C at 760 mmHg
Molecular Weight 159.183 Melting Point (℃) 165 °C
Density 1.1±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C7H13NO3 Flash Point (℃) 172.8±23.2 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description Acetylvaline is an endogenous metabolite.
Target Human Endogenous Metabolite
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Nguyen TV, et al. PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange. Pharm Res. 2007 Feb;24(2):353-60.
Synonyms
(2S)-2-acetamido-3-methylbutanoic acid
Valine, N-acetyl-, L-
EINECS 202-537-8
MFCD00066066
DL-Valine, N-acetyl-
N-Acetyl-L-valine
L-Valine, N-acetyl-
Ac-Val-OH
Product Description
N-Acetyl-L-valine, commonly known as N-Acetylvaline or NAV, is a significant chemical compound with diverse applications in the chemical industry. This product introduction aims to provide an overview of N-Acetyl-L-valine, covering its raw materials, production process, market trends, and the current status of amino acids in the industry.

Raw Materials: N-Acetyl-L-valine is synthesized using L-valine and acetic anhydride as the primary raw materials. L-valine, an essential amino acid, serves as the precursor for N-Acetyl-L-valine synthesis. Acetic anhydride provides the acetyl group necessary for acetylation.

Production Process: The production process of N-Acetyl-L-valine involves the following steps:
Step 1: Esterification reaction - L-valine is reacted with acetic anhydride in the presence of suitable catalysts and reaction conditions to form N-Acetyl-L-valine. The reaction takes place in a solvent or under solid-state conditions, depending on the specific manufacturing process.

Step 2: Purification and refinement - The resulting N-Acetyl-L-valine is purified and refined using techniques such as filtration, crystallization, and chromatography to achieve the desired level of purity.

Market Trends: The market demand for N-Acetyl-L-valine has been steadily increasing due to its diverse applications across various industries. Here are some key market trends:
Pharmaceuticals: N-Acetyl-L-valine is utilized in the pharmaceutical industry. It is used as an ingredient in the formulation of drugs targeting neurological disorders, cognitive function, and muscle health. It may also have applications in the development of sports nutrition products.

Food and Beverage: N-Acetyl-L-valine finds applications in the food and beverage industry. It is used as a flavor enhancer and can contribute to the savory or umami taste in food products. It is particularly used in savory snacks, seasonings, and ready-to-eat meals.

Chemical Research: N-Acetyl-L-valine serves as a valuable compound in chemical research. It is used as a building block in the synthesis of peptides, pharmaceutical intermediates, and specialty chemicals. Its unique structure and functional groups make it useful for diverse synthetic applications.

Current Status of Amino Acids: Amino acids play a crucial role in various sectors, including pharmaceuticals, food additives, animal nutrition, and agriculture. The demand for amino acids continues to grow due to their diverse applications and essential role in biological processes. Essential amino acids, such as L-valine, are of particular importance as they cannot be synthesized by the human body and must be obtained through diet or supplementation.

Conclusion: N-Acetyl-L-valine, derived from L-valine, holds significant value in the chemical industry. Its production involves the combination of raw materials and precise manufacturing processes. The market demand for N-Acetyl-L-valine is driven by its applications in pharmaceuticals, food and beverage, and chemical research. Amino acids, including L-valine, continue to play a vital role in various industries, and N-Acetyl-L-valine maintains its position as a valuable chemical compound with diverse applications.

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