N-acetyl-L-proline
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names N-acetyl-L-proline
Structure
CAS No. 68-95-1 Boiling Point (℃) 366.2±35.0 °C at 760 mmHg
Molecular Weight 157.167 Melting Point (℃) 115-117 °C
Density 1.3±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C7H11NO3 Flash Point (℃) 175.3±25.9 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description DL-Lysine (Lysine) is an α-amino acid that is used in the biosynthesis of proteins.
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Nguyen TV, et al. PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange. Pharm Res. 2007 Feb;24(2):353-60.
Synonyms
N-Acetyl-L-proline
EINECS 200-698-9
Proline, 1-acetyl-, L-
MFCD00020837
(2S)-1-acetylpyrrolidine-2-carboxylic acid
L-Proline, 1-acetyl-
1-Acetyl-L-proline
N-Acethyl-L-proline
Ac-Pro-OH
Product Description
Introduction:
N-Acetyl-L-Proline is a chemical compound derived from proline, a non-essential amino acid. It is widely used in various industries, including pharmaceuticals, cosmetics, and food additives. N-Acetyl-L-Proline offers unique properties and potential benefits, making it a valuable ingredient in different applications.

Raw Materials:
N-Acetyl-L-Proline is synthesized through the acetylation of L-Proline using acetic anhydride or acetic acid as the acetylating agent. L-Proline, the primary raw material, is typically obtained through fermentation processes or chemical synthesis. Acetic anhydride or acetic acid is used to introduce the acetyl group to the L-Proline molecule, resulting in N-Acetyl-L-Proline.

Production Process:
The production of N-Acetyl-L-Proline involves the acetylation of L-Proline under controlled reaction conditions. The acetylation reaction is carried out using suitable catalysts and reaction parameters to ensure high yield and purity of the product. After the acetylation step, the N-Acetyl-L-Proline is subjected to purification processes such as crystallization or filtration to obtain a refined form.

Market Trends:
N-Acetyl-L-Proline has gained significant attention in the pharmaceutical and cosmetic industries due to its potential benefits and diverse applications. It is known for its moisturizing and skin-conditioning properties, making it an attractive ingredient in skincare products. N-Acetyl-L-Proline is also studied for its potential role in collagen synthesis and wound healing. Furthermore, its use as a food additive to enhance flavor and improve texture is being explored.

Amino Acid Status:
L-Proline is a non-essential amino acid that plays a crucial role in protein synthesis, collagen formation, and wound healing. The acetylation of L-Proline in N-Acetyl-L-Proline modifies its chemical structure, potentially enhancing its solubility and bioavailability. This modified form of L-Proline expands its applications and provides additional benefits in various industries.

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