N-acetyl-L-phenylalanine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names N-acetyl-L-phenylalanine
Structure
CAS No. 2018-61-3 Boiling Point (℃) 453.9±38.0 °C at 760 mmHg
Molecular Weight 207.226 Melting Point (℃) 171-173 °C(lit.)
Density 1.2±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C11H13NO3 Flash Point (℃) 228.3±26.8 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description DL-Lysine (Lysine) is an α-amino acid that is used in the biosynthesis of proteins.
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Nguyen TV, et al. PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange. Pharm Res. 2007 Feb;24(2):353-60.
Synonyms
D-Phenylalanine, N-acetyl-
N-Acetyl-3-phenyl-L-alanine
(2R)-2-acetamido-3-phenylpropanoic acid
N-Acetyl-D-phenylalanine
N-Acetyl-l-Phenylalanine
Acetyl-L-phenylalanine
(S)-2-Acetamido-3-phenylpropanoic acid
EINECS 217-959-8
N-acetyl-D,L-phenylalanine
(2S)-2-acetamido-3-phenylpropanoic acid
L-N-Acetylphenylalanine
MFCD00063158
Ac-Phe-OH
Acetyl-D-Phenylalanine
acetylphenylalanine
Ac-D-Phe-OH
Product Description
Introduction: N-Acetyl-L-phenylalanine, commonly known as N-Acetylphenylalanine or NAPA, is an essential chemical compound with significant applications in the chemical industry. This product introduction aims to provide an overview of N-Acetyl-L-phenylalanine, covering its raw materials, production process, market trends, and the current status of amino acids in the industry.

Raw Materials: N-Acetyl-L-phenylalanine is synthesized through a combination of raw materials, primarily L-phenylalanine and acetic acid. L-phenylalanine, an essential amino acid, serves as the precursor for NAPA synthesis. Acetic acid, commonly derived from petrochemical sources or fermentation processes, provides the acetyl group necessary for the acetylation of L-phenylalanine.

Production Process: The production process of N-Acetyl-L-phenylalanine involves the following steps:
Step 1: Extraction of L-phenylalanine - L-phenylalanine is typically obtained from natural sources, such as protein-rich food products or fermentation of microbial cultures.

Step 2: Acetylation reaction - L-phenylalanine is reacted with acetic acid in the presence of suitable catalysts and reaction conditions to form N-Acetyl-L-phenylalanine. The reaction may take place in a solvent or in the solid state, depending on the specific manufacturing process.

Step 3: Purification and refining - The resulting N-Acetyl-L-phenylalanine is purified using various techniques, such as filtration, crystallization, and chromatography, to achieve the desired level of purity.

Market Trends: The market demand for N-Acetyl-L-phenylalanine has been steadily increasing due to its versatile applications across various industries. Here are some key market trends:
Pharmaceutical Industry: N-Acetyl-L-phenylalanine finds extensive use as a building block for the synthesis of novel pharmaceutical compounds. Its role as a precursor in drug discovery and development processes makes it a valuable ingredient in the pharmaceutical sector.

Nutraceuticals and Dietary Supplements: The growing awareness regarding health and wellness has fueled the demand for amino acid-based nutraceuticals and dietary supplements. N-Acetyl-L-phenylalanine's inclusion in these products is driven by its potential to support cognitive function and mood enhancement.

Cosmetics and Personal Care: N-Acetyl-L-phenylalanine's skin-whitening properties have gained attention in the cosmetics industry. It is utilized as an ingredient in skin care products, particularly those aimed at reducing pigmentation and promoting even skin tone.

Current Status of Amino Acids: Amino acids play a crucial role in various sectors, including pharmaceuticals, food additives, animal nutrition, and agriculture. The demand for amino acids continues to grow due to their diverse applications. In particular, the market for essential amino acids, including phenylalanine, remains robust due to their importance in protein synthesis and their therapeutic potential.

Conclusion: N-Acetyl-L-phenylalanine, a derivative of L-phenylalanine, holds significant value in the chemical industry. Its synthesis involves the combination of raw materials and precise production processes. The market demand for N-Acetyl-L-phenylalanine is driven by its applications in pharmaceuticals, nutraceuticals, cosmetics, and personal care. As amino acids continue to play a vital role across multiple industries, N-Acetyl-L-phenylalanine maintains its position as a valuable chemical compound in the market.

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