N-acetyl-L-leucine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names N-Acetyl-L-leucine
Structure
CAS No. 1188-21-2 Boiling Point (℃) 369.6±25.0 °C at 760 mmHg
Molecular Weight 173.21 Melting Point (℃) 187-190 °C(lit.)
Density 1.1±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C8H15NO3 Flash Point (℃) 177.4±23.2 °C
Solubility 0.81 g/100 mL (20 ºC) Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description DL-Lysine (Lysine) is an α-amino acid that is used in the biosynthesis of proteins.
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Nguyen TV, et al. PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange. Pharm Res. 2007 Feb;24(2):353-60.
Synonyms
(S)-N-Acetylleucine
N-Acetyl-L-leucine
(E)-N-(1-Hydroxyethylidene)-L-leucine
Leucine, N-acetyl-, L-
(S)-N-acetyl-leucine
EINECS 214-706-3
L-Leucine, N-acetyl-
L-Leucine, N-acetyl
(S)-2-Acetamido-4-methylpentanoic acid
Acetyl-L-Leucine
L-Leucine, N-(1-hydroxyethylidene)-, (E)-
MFCD00026498
Acetylleucine
Ac-Leu-OH
Product Description
Introduction: N-Acetyl-L-leucine, commonly known as N-Acetylleucine or NAL, is a vital chemical compound with significant applications in the chemical industry. This product introduction aims to provide an overview of N-Acetyl-L-leucine, covering its raw materials, production process, market trends, and the current status of amino acids in the industry.

Raw Materials: N-Acetyl-L-leucine is synthesized through the combination of raw materials, primarily L-leucine and acetic acid. L-leucine, an essential amino acid, serves as the precursor for NAL synthesis. Acetic acid, commonly derived from petrochemical sources or fermentation processes, provides the acetyl group necessary for the acetylation of L-leucine.

Production Process:
The production process of N-Acetyl-L-leucine involves the following steps:
Step 1: Extraction of L-leucine - L-leucine is typically obtained from natural sources, such as protein-rich food products or fermentation of microbial cultures.

Step 2: Acetylation reaction - L-leucine is reacted with acetic acid in the presence of suitable catalysts and reaction conditions to form N-Acetyl-L-leucine. The reaction may take place in a solvent or in the solid state, depending on the specific manufacturing process.

Step 3: Purification and refining - The resulting N-Acetyl-L-leucine is purified using various techniques, such as filtration, crystallization, and chromatography, to achieve the desired level of purity.

Market Trends: The market demand for N-Acetyl-L-leucine has been steadily increasing due to its versatile applications across various industries. Here are some key market trends: Pharmaceutical Industry: N-Acetyl-L-leucine finds extensive use in the pharmaceutical industry as a pharmaceutical ingredient. It is utilized in the formulation of drugs and therapies targeting neurological disorders, cognitive function, and vestibular disorders.

Nutraceuticals and Dietary Supplements: The demand for amino acid-based nutraceuticals and dietary supplements is on the rise. N-Acetyl-L-leucine's inclusion in these products is driven by its potential to support muscle growth, athletic performance, and overall well-being.

Chemical Research: N-Acetyl-L-leucine serves as a valuable compound in chemical research, specifically in the development of new catalysts, ligands, and specialty chemicals. Its unique properties and functional groups make it a valuable tool for synthetic chemists.

Current Status of Amino Acids: Amino acids are essential building blocks in numerous industries, including pharmaceuticals, food additives, animal nutrition, and agriculture. The market for amino acids continues to expand due to their crucial role in protein synthesis and their diverse applications. Essential amino acids, such as leucine, hold significant importance in the industry.

Conclusion: N-Acetyl-L-leucine, derived from L-leucine, is a valuable compound in the chemical industry. Its production involves the combination of raw materials and precise manufacturing processes. The market demand for N-Acetyl-L-leucine is driven by its applications in pharmaceuticals, nutraceuticals, and chemical research. Amino acids, including leucine, continue to play a vital role in various industries, and N-Acetyl-L-leucine maintains its position as a valuable chemical compound with wide-ranging applications.

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