N-acetyl-L-glycine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Ac-Gly-OH
Structure
CAS No. 543-24-8 Boiling Point (℃) 405.1±28.0 °C at 760 mmHg
Molecular Weight 117.103 Melting Point (℃) 207-209 °C(lit.)
Density 1.2±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C4H7NO3 Flash Point (℃) 198.8±24.0 °C
Solubility 2.7 g/100 mL (15 ºC) Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description N-Acetylglycine is a minor constituent of numerous foods with no genotoxicity or acute toxicity. N-acetylglycine is used in biological research of peptidomimetics.
Target Human Endogenous Metabolite
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Harper MS, et al. Toxicology studies with N-acetylglycine. Food Chem Toxicol. 2010 May;48(5):1321-7.
Synonyms
N-acetyl-Gly
ACETYL-GLYCIN
Aceturic acid
N-Acetylglycine
CH3CONHCH2COOH
Glycine, N-acetyl-
ACETYGLYCINE
acetylaminoacetic acid
Ethanoylaminoethanoic acid
N-Ac-Gly-OH
ACETYL-GLYCINE
ACETOGLYCINE
MFCD00004275
Product Description
Introduction: N-Acetyl-L-glycine, commonly known as N-Acetylglycine or NAG, is a significant chemical compound with diverse applications in the chemical industry. This product introduction aims to provide an overview of N-Acetyl-L-glycine, covering its raw materials, production process, market trends, and the current status of amino acids in the industry.

Raw Materials: N-Acetyl-L-glycine is synthesized using L-glycine and acetic anhydride as the primary raw materials. L-glycine, a non-essential amino acid, serves as the precursor for NAG synthesis. Acetic anhydride provides the acetyl group necessary for acetylation.

Production Process:
The production process of N-Acetyl-L-glycine involves the following steps:
Step 1: Esterification reaction - L-glycine is reacted with acetic anhydride in the presence of suitable catalysts and reaction conditions to form N-Acetyl-L-glycine. The reaction takes place in a solvent or under solid-state conditions, depending on the specific manufacturing process.

Step 2: Purification and refinement - The resulting N-Acetyl-L-glycine is purified and refined using techniques such as filtration, crystallization, and chromatography to achieve the desired level of purity.

Market Trends: The market demand for N-Acetyl-L-glycine has been steadily increasing due to its diverse applications across various industries. Here are some key market trends: Pharmaceuticals and Nutraceuticals: N-Acetyl-L-glycine is utilized in the pharmaceutical and nutraceutical industries. It is used as an ingredient in the formulation of drugs, dietary supplements, and functional foods targeting various health benefits, including liver health, cognitive support, and stress reduction.

Cosmetics and Personal Care: N-Acetyl-L-glycine finds applications in cosmetics and personal care products. It is used in skincare formulations due to its potential to promote skin hydration, improve skin texture, and enhance overall skin health.

Chemical Research: N-Acetyl-L-glycine serves as a valuable compound in chemical research. It is utilized as a building block in the synthesis of peptides, pharmaceutical intermediates, and specialty chemicals. Its unique structure and functional groups make it useful for diverse synthetic applications.

Current Status of Amino Acids: Amino acids play a crucial role in various sectors, including pharmaceuticals, food additives, animal nutrition, and agriculture. The demand for amino acids continues to grow due to their diverse applications and essential role in biological processes. Both essential and non-essential amino acids are widely utilized in the industry.

Conclusion: N-Acetyl-L-glycine, derived from L-glycine, holds significant value in the chemical industry. Its production involves the combination of raw materials and precise manufacturing processes. The market demand for N-Acetyl-L-glycine is driven by its applications in pharmaceuticals, nutraceuticals, cosmetics, personal care, and chemical research. Amino acids, including L-glycine, continue to play a vital role in various industries, and N-Acetyl-L-glycine maintains its position as a valuable chemical compound with diverse applications.

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