N-acetyl-L-glutamic acid
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names N-Acetyl-L-glutamic acid
Structure
CAS No. 1188-37-0 Boiling Point (℃) 495.9±35.0 °C at 760 mmHg
Molecular Weight 189.166 Melting Point (℃) 194-196 °C(lit.)
Density 1.4±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C7H11NO5 Flash Point (℃) 253.7±25.9 °C
Solubility 2.7 g/100 mL (20 ºC) Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description N-Acetyl-L-glutamic acid, a N-acyl-L-amino acid, is a component of animal cell culturing media. N-Acetyl-L-glutamic acid is a metabolite of Saccharomyces cerevisiae and human[1].
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. M Hashimoto, et al. Animal cell culturing media containing N-acetyl-L-glutamic acid. Patent.
Synonyms
(2S)-2-(acetylamino)pentanedioic acid
EINECS 214-708-4
N-Acetyl-L-glutamicacid
AC-GLU-OH
N-acetyl-L-glutamate
(S)-2-acetamidopentanedioic acid
N-ACETYL-L-GLU
N-AC-L-GLU
MFCD00002802
N-Acetyl-L-Glutamic
N-Acetyl-L-glutamic Acid
Product Description
Introduction: N-Acetyl-L-glutamic acid, also known as N-Acetylglutamate or NAG, is a significant chemical compound with diverse applications in the chemical industry. This product introduction aims to provide an overview of N-Acetyl-L-glutamic acid, covering its raw materials, production process, market trends, and the current status of amino acids in the industry.

Raw Materials: N-Acetyl-L-glutamic acid is synthesized using L-glutamic acid and acetic anhydride as the primary raw materials. L-glutamic acid, a nonessential amino acid, serves as the precursor for N-Acetyl-L-glutamic acid synthesis. Acetic anhydride provides the acetyl group necessary for acetylation.

Production Process: The production process of N-Acetyl-L-glutamic acid involves the following steps:
Step 1: Esterification reaction - L-glutamic acid is reacted with acetic anhydride in the presence of suitable catalysts and reaction conditions to form N-Acetyl-L-glutamic acid. The reaction takes place in a solvent or under solid-state conditions, depending on the specific manufacturing process.

Step 2: Purification and refinement - The resulting N-Acetyl-L-glutamic acid is purified and refined using techniques such as filtration, crystallization, and chromatography to achieve the desired level of purity.

Market Trends: The market demand for N-Acetyl-L-glutamic acid has been steadily increasing due to its diverse applications across various industries. Here are some key market trends: Pharmaceuticals: N-Acetyl-L-glutamic acid is used in the pharmaceutical industry. It is employed as a pharmaceutical intermediate and in the formulation of drugs targeting neurological disorders, metabolic disorders, and as a dietary supplement.

Food and Beverage: N-Acetyl-L-glutamic acid finds applications in the food and beverage industry. It is used as a flavor enhancer, known for its ability to enhance the umami taste in food products. It is particularly used in savory snacks, seasonings, sauces, and soups.

Chemical Research: N-Acetyl-L-glutamic acid serves as a valuable compound in chemical research. It is used as a building block in the synthesis of peptides, pharmaceutical intermediates, and specialty chemicals. Its unique structure and functional groups make it useful for diverse synthetic applications.

Current Status of Amino Acids: Amino acids play a crucial role in various sectors, including pharmaceuticals, food additives, animal nutrition, and agriculture. The demand for amino acids continues to grow due to their diverse applications and essential role in biological processes. Nonessential amino acids, such as L-glutamic acid, are of particular importance as they can be synthesized by the human body but are also obtained from dietary sources.

Conclusion: N-Acetyl-L-glutamic acid, derived from L-glutamic acid, holds significant value in the chemical industry. Its production involves the combination of raw materials and precise manufacturing processes. The market demand for N-Acetyl-L-glutamic acid is driven by its applications in pharmaceuticals, food and beverage, and chemical research. Amino acids, including L-glutamic acid, continue to play a vital role in various industries, and N-Acetyl-L-glutamic acid maintains its position as a valuable chemical compound with diverse applications.

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