N-acetyl-DL-tryptophan
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names N-Acetyl-DL-tryptophan
Structure
CAS No. 87-32-1 Boiling Point (℃) 586.6±45.0 °C at 760 mmHg
Molecular Weight 246.262 Melting Point (℃) 204-206 °C (dec.)(lit.)
Density 1.3±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C13H14N2O3 Flash Point (℃) 308.6±28.7 °C
Solubility INSOLUBLE IN COLD WATER Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description DL-Lysine (Lysine) is an α-amino acid that is used in the biosynthesis of proteins.
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Nguyen TV, et al. PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange. Pharm Res. 2007 Feb;24(2):353-60.
Synonyms
AmbotzAAA1932
2-acetamido-3-(1H-indol-3-yl)propanoic acid
UNII:4460NBV53F
Tryptophan, N-acetyl-
N-Acetyltryptophan
(R)-2-Acetamido-3-(1H-indol-3-yl)propanoic acid
D-Tryptophan,N-acetyl
D-Tryptophan, N-acetyl-
N-Acetyl-Trp-OH
Ac-D-Trp-OH
Ac-D-tryptophan
MFCD00005644
N-Acetyl-D-tryptophan
Product Description
Introduction: N-Acetyl-DL-tryptophan, commonly known as N-Acetyltryptophan or NADT, is a significant chemical compound with wide-ranging applications in the chemical industry. This product introduction aims to provide an overview of N-Acetyl-DL-tryptophan, covering its raw materials, production process, market trends, and the current status of amino acids in the industry.

Raw Materials: N-Acetyl-DL-tryptophan is synthesized using DL-tryptophan and acetic anhydride as the primary raw materials. DL-tryptophan, an essential amino acid, serves as the precursor for NADT synthesis. Acetic anhydride, derived from acetic acid, provides the acetyl group necessary for acetylation.

Production Process: The production process of N-Acetyl-DL-tryptophan involves the following steps:
Step 1: Extraction of DL-tryptophan - DL-tryptophan can be obtained from natural sources, such as protein-rich foods or fermentation of microbial cultures.

Step 2: Acetylation reaction - DL-tryptophan is reacted with acetic anhydride in the presence of suitable catalysts and reaction conditions to form N-Acetyl-DL-tryptophan. The reaction takes place in a solvent or under solid-state conditions, depending on the specific manufacturing process.

Step 3: Purification and refinement - The resulting N-Acetyl-DL-tryptophan is purified using techniques such as filtration, crystallization, and chromatography to achieve the desired level of purity.

Market Trends: The market demand for N-Acetyl-DL-tryptophan has been steadily increasing due to its versatile applications across various industries. Here are some key market trends: Pharmaceutical Industry: N-Acetyl-DL-tryptophan finds extensive use in the pharmaceutical industry. It is utilized as a precursor for the synthesis of drugs and therapeutic compounds targeting neurological disorders, mood regulation, and sleep disorders.

Nutraceuticals and Dietary Supplements: N-Acetyl-DL-tryptophan is widely used in the production of nutraceuticals and dietary supplements. Its inclusion in these products is driven by its potential to support mood enhancement, stress reduction, and sleep quality.

Chemical Research: N-Acetyl-DL-tryptophan serves as a valuable compound in chemical research, particularly in the development of new pharmaceutical intermediates, catalysts, and specialty chemicals. Its unique structure and functional groups make it a valuable tool for synthetic chemists.

Current Status of Amino Acids: Amino acids play a crucial role in various sectors, including pharmaceuticals, food additives, animal nutrition, and agriculture. The demand for amino acids continues to grow due to their diverse applications and essential role in biological processes. Both essential and non-essential amino acids are widely utilized in the industry.

Conclusion: N-Acetyl-DL-tryptophan, derived from DL-tryptophan, holds significant value in the chemical industry. Its production involves the combination of raw materials and precise manufacturing processes. The market demand for N-Acetyl-DL-tryptophan is driven by its applications in pharmaceuticals, nutraceuticals, dietary supplements, and chemical research. Amino acids, including DL-tryptophan, continue to play a vital role in various industries, and N-Acetyl-DL-tryptophan maintains its position as a valuable chemical compound with diverse applications.

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