N-acetyl-DL-leucine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
Free Quote
For samples, pricing, or more information, please call us at 0086-25-52397805 or mail to info@alchemist-chem.com or fill out the following form.
We will respond to you as soon as possible.

Tel: 0086-25-52397805

Email: info@alchemist-chem.com

General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Acetylleucine
Structure
CAS No. 99-15-0 Boiling Point (℃) 369.6±25.0 °C at 760 mmHg
Molecular Weight 173.21 Melting Point (℃) 160ºC
Density 1.1±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C8H15NO3 Flash Point (℃) 177.4±23.2 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description Acetylleucine is a drug used in the treatment of vertigo.
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Nguyen TV, et al. PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange. Pharm Res. 2007 Feb;24(2):353-60.
Synonyms
Ac-D-Leu-OH
D-Leucine, N-acetyl-
Leucine, N-acetyl-, DL-
Ac-DL-Leu-OH
Leucine, N-acetyl-
2-acetamido-4-methylpentanoic acid
DL-Leucine, N-acetyl-
(R)-N-acetyl-leucine
Ac-Leu-OH
N-Acetylleucine
(R)-2-Acetamido-4-methylpentanoic acid
UNII:K76S41V71X
EINECS 202-734-9
MFCD00026498
N-acetyl-leucine
(2R)-2-acetamido-4-methylpentanoic acid
Acetylleucine
Product Description
Introduction:
N-Acetyl-DL-leucine, commonly known as N-Acetylleucine or NAL, is a significant chemical compound with diverse applications in the chemical industry. This product introduction aims to provide an overview of N-Acetyl-DL-leucine, covering its raw materials, production process, market trends, and the current status of amino acids in the industry.

Raw Materials:
N-Acetyl-DL-leucine is synthesized using DL-leucine and acetic anhydride as the primary raw materials. DL-leucine, an essential amino acid, serves as the precursor for NAL synthesis. Acetic anhydride provides the acetyl group necessary for acetylation.

Production Process:
The production process of N-Acetyl-DL-leucine involves the following steps:
Step 1: Esterification reaction - DL-leucine is reacted with acetic anhydride in the presence of suitable catalysts and reaction conditions to form N-Acetyl-DL-leucine. The reaction takes place in a solvent or under solid-state conditions, depending on the specific manufacturing process.

Step 2: Purification and refinement - The resulting N-Acetyl-DL-leucine is purified and refined using techniques such as filtration, crystallization, and chromatography to achieve the desired level of purity.

Market Trends:
The market demand for N-Acetyl-DL-leucine has been steadily increasing due to its diverse applications across various industries. Here are some key market trends: Pharmaceuticals: N-Acetyl-DL-leucine is widely used in the pharmaceutical industry. It is utilized as an active pharmaceutical ingredient (API) in the formulation of drugs targeting neurological disorders, cognitive health, and nervous system support.

Sports and Performance Nutrition: N-Acetyl-DL-leucine finds applications in the sports and performance nutrition sector. It is included in pre-workout and intra-workout supplements to enhance athletic performance, muscle recovery, and endurance.

Chemical Research: N-Acetyl-DL-leucine serves as a valuable compound in chemical research. It is used as a building block in the synthesis of peptides, pharmaceutical intermediates, and specialty chemicals. Its unique structure and functional groups make it useful for diverse synthetic applications.

Current Status of Amino Acids:
Amino acids play a crucial role in various sectors, including pharmaceuticals, food additives, animal nutrition, and agriculture. The demand for amino acids continues to grow due to their diverse applications and essential role in biological processes. Essential amino acids, such as DL-leucine, are of particular importance as they cannot be synthesized by the human body and must be obtained through diet or supplementation.

Conclusion:
N-Acetyl-DL-leucine, derived from DL-leucine, holds significant value in the chemical industry. Its production involves the combination of raw materials and precise manufacturing processes. The market demand for N-Acetyl-DL-leucine is driven by its applications in pharmaceuticals, sports nutrition, and chemical research. Amino acids, including DL-leucine, continue to play a vital role in various industries, and N-Acetyl-DL-leucine maintains its position as a valuable chemical compound with diverse applications.

Leave A Message
Leave A Message ×
If you are interested in our products and want to know more details,please leave a message here,we will reply you as soon as we can.