N-acetyl-D-tryptophan
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names (R)-2-Acetamido-3-(1H-indol-3-yl)propanoic acid
Structure
CAS No. 2280-01-5 Boiling Point (℃) 586.6±45.0 °C at 760 mmHg
Molecular Weight 246.262 Melting Point (℃) 186ºC
Density 1.3±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C13H14N2O3 Flash Point (℃) 308.6±28.7 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description DL-Lysine (Lysine) is an α-amino acid that is used in the biosynthesis of proteins.
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Nguyen TV, et al. PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange. Pharm Res. 2007 Feb;24(2):353-60.
Synonyms
AmbotzAAA1932
MFCD00065021
UNII:4460NBV53F
Tryptophan, N-acetyl-
N-Acetyltryptophan
(R)-2-Acetamido-3-(1H-indol-3-yl)propanoic acid
D-Tryptophan,N-acetyl
EINECS 218-912-4
D-Tryptophan, N-acetyl-
N-Acetyl-Trp-OH
Ac-D-Trp-OH
Ac-D-tryptophan
N-Acetyl-D-tryptophan
2-(acetylamino)-3-(1H-indol-3-yl)propanoic acid
N-Acetyl-DL-tryptophan
Nb-acetyl-D-tryptophan
(2R)-2-acetamido-3-(1H-indol-3-yl)propanoic acid
Product Description
Introduction: N-Acetyl-D-Tryptophan is a chemical compound derived from tryptophan, an essential amino acid. It is widely used in the pharmaceutical industry for various applications due to its unique chemical structure and potential therapeutic properties. N-Acetyl-D-Tryptophan offers a range of benefits and is highly sought after for its potential impact on human health.

Raw Materials: N-Acetyl-D-Tryptophan is produced by acetylating D-Tryptophan using acetic anhydride or acetic acid as the acetylating agent. D-Tryptophan, the primary raw material, is typically obtained through chemical synthesis or enzymatic methods. Acetic anhydride or acetic acid is used to introduce the acetyl group to the D-Tryptophan molecule, resulting in N-Acetyl-D-Tryptophan.

Production Process: The production of N-Acetyl-D-Tryptophan involves the acetylation of D-Tryptophan under controlled reaction conditions. The acetylation reaction is carried out using appropriate catalysts and reaction parameters to ensure a high yield and purity of the product. The resulting N-Acetyl-D-Tryptophan is then subjected to purification techniques, such as crystallization or chromatography, to obtain a refined and stable form.

Market Trends: N-Acetyl-D-Tryptophan has garnered significant interest in the pharmaceutical industry due to its potential therapeutic applications. As an acetylated form of D-Tryptophan, it may offer enhanced bioavailability and stability compared to its unmodified counterpart. N-Acetyl-D-Tryptophan is studied for its potential role in neurotransmitter regulation, mood enhancement, and sleep disorders. It may also have applications in the development of novel drugs targeting various physiological processes.

Amino Acid Status: D-Tryptophan is an essential amino acid that serves as a precursor for the synthesis of important molecules such as serotonin and melatonin. The acetylation of D-Tryptophan enhances its chemical properties and potentially improves its absorption and bioavailability. N-Acetyl-D-Tryptophan's unique structure and modified form expand the possibilities for its use in pharmaceutical research and development.

Conclusion: N-Acetyl-D-Tryptophan is a chemically modified derivative of D-Tryptophan, offering potential therapeutic applications in the pharmaceutical industry. Its production involves the acetylation of D-Tryptophan under controlled conditions, ensuring consistent product quality. With its unique properties and potential benefits, N-Acetyl-D-Tryptophan continues to be an area of interest for research and development in the pharmaceutical field. As understanding of amino acids and their derivatives advances, N-Acetyl-D-Tryptophan may contribute to the development of innovative drugs and therapies targeting various physiological processes.

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