N-acetyl-D-proline
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names N-Acetyl-D-Proline
Structure
CAS No. 59785-68-1 Boiling Point (℃) 366.2±35.0 °C at 760 mmHg
Molecular Weight 157.167 Melting Point (℃) N/A
Density 1.3±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C7H11NO3 Flash Point (℃) 175.3±25.9 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description DL-Lysine (Lysine) is an α-amino acid that is used in the biosynthesis of proteins.
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Nguyen TV, et al. PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange. Pharm Res. 2007 Feb;24(2):353-60.
Synonyms
1-Acetyl-D-proline
D-Proline, 1-acetyl-
(2R)-1-acetylpyrrolidine-2-carboxylic acid
Ac-D-Pro-OH
Product Description
Introduction:
N-Acetyl-D-proline, also known as N-Acetyldihydroxyproline or NADP, is a crucial chemical compound with significant applications in the chemical industry. This product introduction aims to provide an overview of N-Acetyl-D-proline, covering its raw materials, production process, market trends, and the current status of amino acids in the industry.

Raw Materials:
N-Acetyl-D-proline is synthesized using D-proline and acetic anhydride as the primary raw materials. D-proline, a non-essential amino acid, serves as the precursor for NADP synthesis. Acetic anhydride, derived from acetic acid, provides the acetyl group necessary for acetylation.

Production Process:
The production process of N-Acetyl-D-proline involves the following steps:
Step 1: Extraction of D-proline - D-proline can be obtained through various methods, including microbial fermentation or chemical synthesis.

Step 2: Acetylation reaction - D-proline is reacted with acetic anhydride in the presence of appropriate catalysts and reaction conditions to form N-Acetyl-D-proline. The reaction takes place in a solvent or under solid-state conditions, depending on the specific manufacturing process.

Step 3: Purification and refinement - The resulting N-Acetyl-D-proline is purified using techniques such as filtration, crystallization, and chromatography to achieve the desired level of purity.

Market Trends:
The market demand for N-Acetyl-D-proline has been steadily increasing due to its versatile applications across various industries. Here are some key market trends: Pharmaceutical Industry: N-Acetyl-D-proline finds extensive use in the pharmaceutical industry. It is utilized as a building block in the synthesis of peptides and pharmaceutical intermediates. Its unique structural characteristics make it valuable in drug discovery and development processes.

Cosmetics and Personal Care: N-Acetyl-D-proline's moisturizing and anti-aging properties have gained attention in the cosmetics and personal care industry. It is used as an ingredient in skincare products, particularly those focused on hydration, collagen synthesis, and wrinkle reduction.

Food and Beverage: N-Acetyl-D-proline is also employed as a food additive and flavor enhancer. It can improve the taste and aroma of various food products, including soups, sauces, and savory snacks.

Current Status of Amino Acids:
Amino acids play a vital role in various sectors, including pharmaceuticals, food additives, animal nutrition, and agriculture. The demand for amino acids continues to grow due to their diverse applications and essential role in biological processes. Amino acids, both essential and non-essential, are widely utilized in the industry.

Conclusion:
N-Acetyl-D-proline, derived from D-proline, holds significant value in the chemical industry. Its production involves the combination of raw materials and precise manufacturing processes. The market demand for N-Acetyl-D-proline is driven by its applications in pharmaceuticals, cosmetics, personal care, and the food industry. Amino acids, including D-proline, continue to play a vital role in various industries, and N-Acetyl-D-proline maintains its position as a valuable chemical compound with diverse applications.

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