Methyl L-pyroglutamate
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Methyl L-Pyroglutamate
Structure
CAS No. 4931-66-2 Boiling Point (℃) 304.7±35.0 °C at 760 mmHg
Molecular Weight 143.141 Melting Point (℃) N/A
Density 1.2±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C6H9NO3 Flash Point (℃) 138.1±25.9 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description Methyl L-pyroglutamate ((S)-Methyl 5-oxopyrrolidine-2-carboxylate;L-Pyroglutamic acid methyl ester) is isolated from P. oleracea and has anti-inflammatory activity[1].
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Kim KH, et al. 1-Carbomethoxy-β-Carboline, Derived from Portulaca oleracea L., Ameliorates LPS-Mediated Inflammatory Response Associated with MAPK Signaling and Nuclear Translocation of NF-κB.Molecules. 2019 Nov 7;24(22). pii: E4042.
Synonyms
L-Pyroglutamic Acid Methyl Ester
DL-Proline, 5-oxo-, methyl ester
EINECS 225-567-3
Methyl (S)-(+)-2-Pyrrolidone-5-carboxylate
methyl (2S)-5-oxopyrrolidine-2-carboxylate
(S)-5-Oxopyrrolidine-2-carboxylic Acid Methyl Ester
MFCD00080931
Methyl (S)-5-Oxopyrrolidine-2-carboxylate
L-Proline, 5-oxo-, methyl ester
Methyl 5-oxo-L-prolinate
L-Pyroglutamic acid methylester
Product Description
Introduction: Methyl L-Pyroglutamate is a chemical compound derived from L-pyroglutamic acid, a cyclic amino acid derivative. It finds applications in the pharmaceutical, cosmetic, and research industries due to its unique properties and potential uses.

Raw Materials: Methyl L-Pyroglutamate is synthesized using high-quality raw materials, including L-pyroglutamic acid and methylating agents. L-pyroglutamic acid can be obtained through appropriate chemical reactions or extracted from natural sources, ensuring its purity and effectiveness. The methylating agent is used to introduce the methyl group into the pyroglutamic acid, resulting in Methyl L-Pyroglutamate.

Production Process: The production of Methyl L-Pyroglutamate involves a series of carefully controlled steps to ensure consistent product quality. L-pyroglutamic acid is first obtained from the appropriate source and then reacted with a methylating agent under specific conditions. The reaction mixture undergoes purification techniques such as filtration, crystallization, and drying, resulting in a white crystalline powder as the final product.

Market Trends: Methyl L-Pyroglutamate has gained attention in various industries due to its potential applications. In the pharmaceutical sector, it is used as a building block in the synthesis of pharmaceutical compounds, especially those targeting the central nervous system. In the cosmetic industry, it is utilized for its potential skin rejuvenation and anti-aging properties. Additionally, Methyl L-Pyroglutamate has applications in the research field, particularly in studies related to neurotransmitters and cognitive function.

Amino Acid Status: Methyl L-Pyroglutamate offers unique advantages as an amino acid derivative. L-pyroglutamic acid is a derivative of the amino acid glutamic acid, and the addition of a methyl group enhances its properties and potential applications. Glutamic acid is a non-essential amino acid that plays a crucial role in neurotransmission and brain function. Methyl L-Pyroglutamate may contribute to the modulation of neurotransmitters and cognitive processes, making it of interest in the field of neurochemistry and cognitive enhancement.

Conclusion: Methyl L-Pyroglutamate is a valuable chemical compound with diverse applications in the pharmaceutical, cosmetic, and research industries. Its synthesis from high-quality raw materials and stringent production processes ensure consistent product quality. The market demand for this product is expected to continue growing due to its unique properties and potential applications in drug synthesis, cosmetic formulations, and research studies. With its various applications and potential contributions to brain health and cognitive function, Methyl L-Pyroglutamate offers a valuable option for formulation and application in different industries, providing a convenient means to explore its potential benefits and enhance various aspects of health and well-being.

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