Melanotropin
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names (Nle4,D-Phe7)-α-MSH trifluoroacetate salt
Structure
CAS No. 75921-69-6 Boiling Point (℃) N/A
Molecular Weight 1646.845 Melting Point (℃) N/A
Density 1.5±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C78H111N21O19 Flash Point (℃) N/A
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description Melanotan I is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH), for gaining a tan.
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Langan EA, et al. Melanotropic peptides: more than just 'Barbie drugs' and 'sun-tan jabs'? Br J Dermatol. 2010 Sep;163(3):451-5.
Synonyms
Melanotan
Melanotan I
MFCD00151715
Wiskostatin
N-Acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide
N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-N-(diaminomethylidene)-L-ornithyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide
N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-α-glutamyl-L-histidyl-D-phenylalanyl-N-(diaminomethylidene)-L-ornithyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide
Ac-Ser-Tyr-Ser-Nle-Glu-His-DPhe-Arg-Trp-Gly-Lys-Pro-Val-NH2
L-Valinamide, N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-
L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl- L-Valinamide, N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-α-glutamyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-
L-valinamide, N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-α-glutamyl-L-histidyl-D-phenylalanyl-N-(diaminomethylene)-L-ornithyl-L-tryptophylglycyl-L-lysyl-L-prolyl-
N-Acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-α-glutamyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide
Scenesse
Ac-SYS-Nle-EHfRWGKPV-NH2
Afamelanotide
Product Description
Introduction: Melanotropin is a significant chemical compound with various applications in the chemical industry. This product introduction aims to provide an overview of Melanotropin, covering its raw materials, production process, market trends, and the current status of amino acids in the industry.

Raw Materials: Melanotropin is synthesized using amino acids as the primary raw materials. Specific amino acids, such as L-phenylalanine, L-tyrosine, and L-cysteine, serve as precursors for the synthesis of Melanotropin.

Production Process: The production process of Melanotropin involves the following steps:
Step 1: Peptide Synthesis - Amino acids are selectively combined and chemically modified to form the desired peptide structure of Melanotropin. This process may include solid-phase peptide synthesis, liquid-phase peptide synthesis, or recombinant DNA technology.

Step 2: Purification - The synthesized Melanotropin is purified using techniques such as chromatography, filtration, or crystallization to obtain the desired level of purity and remove any impurities or by-products.

Market Trends: The market demand for Melanotropin has been growing due to its various applications across industries. Here are some key market trends:
Pharmaceuticals: Melanotropin has significant applications in the pharmaceutical industry, particularly in dermatology. It is used for the treatment of certain skin conditions, such as vitiligo and erythropoietic protoporphyria. Melanotropin works by stimulating melanocytes to produce melanin, which helps in skin pigmentation.

Cosmetics: Melanotropin is also utilized in cosmetic formulations, primarily in sunless tanning products and skin-darkening agents. It provides a natural-looking tan by stimulating melanin production without the need for UV exposure.

Current Status of Amino Acids: Amino acids are fundamental building blocks of peptides and proteins. They are essential in various industries, including pharmaceuticals, cosmetics, and biotechnology. Amino acids serve as precursors for the synthesis of Melanotropin and contribute to the advancement of peptide-based products.

Conclusion: Melanotropin, synthesized using amino acids as raw materials, plays a significant role in the chemical industry. Its production involves peptide synthesis and subsequent purification. The market demand for Melanotropin is driven by its applications in pharmaceuticals and cosmetics. Amino acids continue to be crucial components in various industries, contributing to the development of peptide-based products and advancements in skin health and care.

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