L-Pyroglutamic Acid
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names L-Pyroglutamic acid
Structure
CAS No. 98-79-3 Boiling Point (℃) 382.4±52.0 °C at 760 mmHg
Molecular Weight 129.114 Melting Point (℃) 160-163 °C(lit.)
Density 1.6±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C5H7NO3 Flash Point (℃) 185.1±30.7 °C
Solubility 10-15 g/100 mL (20 ºC) Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description L-Pyroglutamic acid is the levo-isomer of Pyroglutamic acid. L-Pyroglutamic acid is the biologically active enantiomer in humans. Pyroglutamic acid is an intermediate in glutathione metabolism.
Target Human Endogenous Metabolite
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Nguyen TV, et al. PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange. Pharm Res. 2007 Feb;24(2):353-60.
Synonyms
EINECS 202-700-3
MFCD00005272
L-Pyroglutamicacid
hydroxy-pyridin-3-yl-acetic acid
5 oxoproline
L-Pyroglutamic acid
H-Pyr-OH
Product Description
L-pyroglutamic acid, also known as 5-oxoproline, is a naturally occurring amino acid derivative that is commonly used in the pharmaceutical and chemical industries. It is a white crystalline powder that is soluble in water and slightly soluble in ethanol. L-pyroglutamic acid is used in a variety of applications, including as an intermediate in the synthesis of pharmaceuticals and as a component of nutritional supplements.

Pharmaceutical Use: L-pyroglutamic acid is used as an intermediate in the synthesis of several important pharmaceuticals, including anti-inflammatory and anti-tumor agents. It has been shown to exhibit anti-inflammatory and anti-oxidant effects, and has been studied for its potential to treat conditions such as Alzheimer's disease and cognitive impairment. It also has potential as a chelating agent for metal ions, which could be useful in the treatment of heavy metal poisoning.

Medical Use: L-pyroglutamic acid has been studied for its potential to improve cognitive function and memory in both healthy individuals and those with cognitive impairment. It is believed to increase the levels of several important neurotransmitters in the brain, including acetylcholine and glutamate. Some studies have also suggested that L-pyroglutamic acid may have neuroprotective properties, and could potentially be useful in the treatment of neurodegenerative disorders such as Alzheimer's disease.

Market Trend: The market for L-pyroglutamic acid is expected to experience steady growth in the coming years, driven by increasing demand from the pharmaceutical and nutraceutical industries. The use of L-pyroglutamic acid as a cognitive enhancer and memory aid is particularly promising, as the demand for such products is increasing rapidly. Furthermore, the use of L-pyroglutamic acid in the treatment of neurodegenerative disorders is a potentially lucrative application that could further drive demand for the compound.

Supply Chain: L-pyroglutamic acid can be produced through the hydrolysis of various natural and synthetic compounds, including glutamic acid and pyrrolidone. It is commonly produced by chemical manufacturers and is available in both pharmaceutical and food-grade qualities. The compound is then distributed through various channels, including pharmaceutical and nutraceutical companies, as well as chemical distributors.

Conclusion: L-pyroglutamic acid is a versatile compound that has numerous potential applications in the pharmaceutical and chemical industries. Its neuroprotective properties and potential as a cognitive enhancer make it an especially promising compound, and demand for L-pyroglutamic acid is expected to continue to grow in the coming years. As such, the market for L-pyroglutamic acid presents a potentially lucrative opportunity for chemical manufacturers and distributors.

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