L-Leucine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names L-leucine
Structure
CAS No. 61-90-5 Boiling Point (℃) 225.8±23.0 °C at 760 mmHg
Molecular Weight 131.173 Melting Point (℃) 286-288 ºC
Density 1.0±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C6H13NO2 Flash Point (℃) 90.3±22.6 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway[1].
Target mTORC1
In Vitro L-Leucine (10 mM) treatment impairs endocrine progenitor cell development[1]. In E13.5 rat pancreatic explants, in absence of added L-Leucine, Ngn3 mRNA levels increased after 1 day of culture, peaked on day 3, and then decreased. When L-Leucine is added, a dramatic decrease is observed in Ngn3 mRNA levels. This decrease in Ngn3 mRNA levels was paralleled by a decrease in the number of Ngn3-expressing cells (4728±408 vs. 959±28; P< 0.01). Finally, L-Leucine also caused a dose-dependent repressive effect on the mRNA levels of the three genes, namely Ngn3, its target Insm1, and insulin[1]. Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation. L-Leucine increases intracellular HIF-1α levels and activates the HIF-1α signaling pathway, and these two effects are mediated by the mTOR signaling pathway. This process results in Ngn3 repression and, consequently, decreases β-cell differentiation[1].
References [1]. Rachdi L, et al. L-leucine alters pancreatic β-cell differentiation and function via the mTor signaling pathway. Diabetes. 2012 Feb;61(2):409-17.
Synonyms
MFCD00002617
Glusate
H-L-GLU-OH
Leucine
L-GLU
(l)-leucine
EINECS 200-522-0
H-GLU-OH
[14C]-L-(+)-Leucine
GLU
Product Description
L-leucine is a naturally occurring amino acid that is essential for protein synthesis in the human body. It is a branched-chain amino acid (BCAA) that is found in high concentrations in animal proteins, such as meat, dairy, and eggs. L-leucine is also used as a dietary supplement and food additive due to its beneficial effects on muscle growth and repair.
From a food grade perspective, L-leucine is a safe and effective ingredient that is widely used in the food industry. It is commonly added to sports nutrition supplements, protein powders, and other health products to support muscle growth, recovery, and performance. L-leucine is also used in food products to enhance their nutritional value and flavor.
The performance benefits of L-leucine are well documented. As a BCAA, L-leucine plays a critical role in muscle protein synthesis, which is the process by which muscle fibers are repaired and regenerated after exercise. L-leucine also helps to reduce muscle damage and soreness, improve endurance, and increase energy levels. These benefits make L-leucine a popular ingredient in sports nutrition products and dietary supplements.
Aside from its performance benefits, L-leucine is also valued for its taste-enhancing properties. L-leucine has a slightly sweet taste and can be used to improve the flavor of food and beverage products. Additionally, L-leucine is highly soluble, which makes it easy to incorporate into a variety of food and beverage applications.
In conclusion, L-leucine is a safe and effective ingredient that is widely used in the food industry. Its beneficial effects on muscle growth, recovery, and performance make it a popular ingredient in sports nutrition products and dietary supplements, while its taste-enhancing properties make it a valuable addition to food and beverage products.
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