L-Hydroxyproline
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names L-Histidine
Structure
CAS No. 51-35-4 Boiling Point (℃) 355.2±42.0 °C at 760 mmHg
Molecular Weight 131.13 Melting Point (℃) 273 °C (dec.)(lit.)
Density 1.4±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C5H9NO3 Flash Point (℃) 168.6±27.9 °C
Solubility 357.8 g/L (20 º C) Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description L-Hydroxyproline, one of the hydroxyproline (Hyp) isomers, is a useful chiral building block in the production of many pharmaceuticals.
Target Human Endogenous Metabolite
In Vitro L-Hydroxyproline (Trans-4-hydroxy-L-proline;Trans-Hyp) has been widely used in medicine, biochemistry, food, cosmetic and other aspects of industry. Additionally, L-Hydroxyproline has also been found in the composition of some secondary metabolites such as actinomycins and echinocandins. L-Hydroxyproline is manufactured industrially most by acid hydrolysis of mammalian collagen because of its rich amount in the collagen[1].
References [1]. Yi Y, et al. Biosynthesis of trans-4-hydroxyproline by recombinant strains of Corynebacterium glutamicum and Escherichia coli. BMC Biotechnol. 2014 May 19;14:44.
Synonyms
4-Hydroxyproline
(2S,4R)-4-hydroxypyrrolidinium-2-carboxylate
Hydroxyproline
MFCD00064320
L-Hydroxyproline
trans-Lachnophyllol
trans-4-hydroxyproline
Proline, 4-hydroxy-, L-
trans-L-4-hydroxyproline
(2S,4R)-(-)-4-Hydroxypyrrolidine-2-carboxylic acid
Proline, 4-hydroxy-
trans-4-Hydroxy-L-proline
dec-2t-ene-4,6-diyn-1-ol
L-trans-4-hydroxyproline
(2S,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid
L-Proline, 4-hydroxy-, trans- (9CI)
L-Proline, 4-hydroxy-, (4R)-
Dec-2t-en-4,6-diin-1-ol
EINECS 200-091-9
Product Description
L-Hydroxyproline is a food additive that is commonly used in the manufacturing of various food products. It is a naturally occurring amino acid that is found in collagen, a protein that is abundant in connective tissues, such as skin, tendons, and bones.
As a food additive, L-Hydroxyproline is primarily used as a flavor enhancer and to improve the texture of processed foods. It has a sweet taste and is often added to food products, such as canned meats and fish, to enhance their flavor. L-Hydroxyproline also acts as a stabilizer and emulsifier in food processing, helping to improve the texture and appearance of various food products.
L-Hydroxyproline is generally regarded as safe for consumption in small amounts and is well-tolerated by most people. It is also found naturally in many foods, including meats, dairy products, and legumes.
In addition to its use as a food additive, L-Hydroxyproline is also available as a dietary supplement. It is often marketed as a supplement that can help support healthy skin, hair, and nails, as well as promote healthy aging and joint health.
Overall, L-Hydroxyproline is a valuable food additive that provides a range of benefits to the food industry. It is commonly used in processed foods to enhance their flavor and improve their texture, and is generally safe for consumption in small amounts. As with any food additive or dietary supplement, it is important to use L-Hydroxyproline in moderation and in accordance with industry guidelines to ensure its safety and efficacy.
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