L-Hydroxyproline methyl ester hydrochloride
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
Free Quote
For samples, pricing, or more information, please call us at 0086-25-52397805 or mail to info@alchemist-chem.com or fill out the following form.
We will respond to you as soon as possible.

Tel: 0086-25-52397805

Email: info@alchemist-chem.com

General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names (2R,4S)-Methyl 4-hydroxypyrrolidine-2-carboxylatehydrochloride
Structure
CAS No. 481704-21-6 Boiling Point (℃) N/A
Molecular Weight 181.617 Melting Point (℃) N/A
Density N/A Vapor Specific Gravity N/A
Molecular Formula C6H12ClNO3 Flash Point (℃) N/A
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description tans-4-Hydroxy-D-proline methyl ester hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). tans-4-Hydroxy-D-proline methyl ester hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2].
Target Non-cleavable
In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
Synonyms
Trans-4-hydroxy-L-proline methyl ester hydrochloride
1-Hydroxy-pentan-2-on
Methyl (4R)-4-hydroxy-L-prolinate hydrochloride (1:1)
1-hydroxy-pentan-2-one
Hydroxymethyl-propyl-keton
1-Hydroxy-2-pentanone
2-Pentanone,1-hydroxy
l-hydroxy-2-oxopentane
L-hydroxyproline methyl ester hydrochloride
L-Proline, 4-hydroxy-, methyl ester, (4R)-, hydrochloride (1:1)
4S-hydroxy-1-pyrrolidine-2R-carboxylic acid methyl ester hydrochloride salt
1-hydroxy-2-oxopentane
Product Description
Introduction: L-Hydroxyproline Methyl Ester Hydrochloride is a chemical compound derived from L-hydroxyproline, a non-essential amino acid with significant biological importance. This product finds wide application in the pharmaceutical, research, and chemical industries due to its unique properties and diverse uses.

Raw Materials: L-Hydroxyproline Methyl Ester Hydrochloride is synthesized using high-quality raw materials, including L-hydroxyproline and methanol. L-hydroxyproline, derived from appropriate chemical reactions or enzymatic processes, serves as the starting material for the synthesis. Methanol, a commonly used solvent and reagent in organic synthesis, is used for esterification to produce L-Hydroxyproline Methyl Ester.

Production Process: The production of L-Hydroxyproline Methyl Ester Hydrochloride involves controlled steps to ensure consistent product quality. L-hydroxyproline is first obtained from a reliable source and then reacted with methanol under specific conditions. The esterification reaction is carefully monitored, and the resulting L-Hydroxyproline Methyl Ester is converted into the hydrochloride salt form for improved stability and solubility. Purification techniques such as crystallization and filtration are employed to obtain a pure and crystalline form of L-Hydroxyproline Methyl Ester Hydrochloride.

Market Trends: L-Hydroxyproline Methyl Ester Hydrochloride has gained significant attention in the pharmaceutical and research industries due to its potential applications. In the pharmaceutical sector, it serves as a valuable intermediate for the synthesis of various drug molecules targeting specific diseases and disorders. It can be used in the development of pharmaceutical intermediates and active pharmaceutical ingredients (APIs). In research, L-Hydroxyproline Methyl Ester Hydrochloride finds applications in peptide synthesis, protein engineering, and drug delivery systems. The market demand for L-Hydroxyproline Methyl Ester Hydrochloride is driven by the continuous need for innovative compounds in drug discovery and research.

Amino Acid Status: L-Hydroxyproline is a non-essential amino acid that plays crucial roles in collagen synthesis and connective tissue formation. By esterifying L-hydroxyproline with methanol, L-Hydroxyproline Methyl Ester Hydrochloride offers enhanced stability and solubility, making it suitable for various applications in the pharmaceutical and chemical industries.

Conclusion: L-Hydroxyproline Methyl Ester Hydrochloride is a valuable compound with diverse applications in the pharmaceutical, research, and chemical industries. Its synthesis from high-quality raw materials and stringent production processes ensure consistent product quality. The market demand for L-Hydroxyproline Methyl Ester Hydrochloride is expected to continue growing due to its unique properties and potential applications in drug discovery, pharmaceutical synthesis, and research endeavors. With its versatile applications and potential contributions to pharmaceutical development and scientific advancements, L-Hydroxyproline Methyl Ester Hydrochloride provides a valuable option for formulation and application in different industries, supporting drug synthesis, peptide chemistry, and research endeavors.

Leave A Message
Leave A Message ×
If you are interested in our products and want to know more details,please leave a message here,we will reply you as soon as we can.