L-Histidine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names L-Histidine
Structure
CAS No. 71-00-1 Boiling Point (℃) 458.9±35.0 °C at 760 mmHg
Molecular Weight 155.16 Melting Point (℃) 282 °C (dec.)(lit.)
Density 1.4±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C6H9N3O2 Flash Point (℃) 231.3±25.9 °C
Solubility 41.6 g/L (25 ºC) Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description L-Hisidine is an essential amino acid for infants. L-Hisidine is an inhibitor of mitochondrial glutamine transport.
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro L-histidine completely inhibits growth and its effect on viability is inversely related to FLO11 expression. L-histidine does not affect the viability of the Δflo11 and S288c strains. L-histidine dramatically decreases air-liquid biofilm formation and adhesion to polystyrene of the flor yeasts with no effect on the transcription level of the FLO11 gene. Moreover, L-histidine modifies the chitin and glycans content on the cell-wall of flor yeasts[1].
References [1]. Bou Zeidan M, et al. L-histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts. PLoS One. 2014 Nov 4;9(11):e112141.
[2]. Rama Rao KV, et al. Brain edema in acute liver failure: inhibition by L-histidine. Am J Pathol. 2010 Mar;176(3):1400-8.
[3]. Yoshikawa T, et al. Insufficient intake of L-histidine reduces brain histamine and causes anxiety-like behaviors in male mice. J Nutr. 2014 Oct;144(10):1637-41.
Synonyms
(S)-a-Amino-1H-imidazole-4-propanoic Acid
(S)-1H-Imidazole-4-alanine
a-Amino-4(or 5)-Imidazolepropionic Acid
d,l-histidine
1H-Imidazole-4-propanoic acid, α-amino-, (S)-
FEMA 3694
(S)-histidine
EINECS 200-745-3
HISTIDINE, L-
His
Histidine
H-L-HIS-OH
3-(1H-imidazol-4-yl)-L-Alanine
hydrogen L-histidinate
L-His
Histidin
L-Histdine
L-Hisidine
MFCD00064315
L-Histidine
Product Description
L-Histidine is a naturally occurring amino acid that is commonly used in the food industry as a food additive. It is an essential amino acid, which means that the body cannot synthesize it and it must be obtained through diet.
As a food additive, L-Histidine is primarily used as a flavor enhancer and to improve the nutritional value of processed foods. It has a slightly sweet taste and is often added to food products, such as meat products, soups, and sauces, to enhance their flavor. L-Histidine is also used as a nutritional supplement in infant formulas and sports drinks.
L-Histidine is generally regarded as safe for consumption in small amounts and is well-tolerated by most people. It is also found naturally in many foods, including meats, fish, and dairy products.
In addition to its use as a food additive, L-Histidine is also available as a dietary supplement. It is often marketed as a supplement that can help support healthy immune function, improve sleep quality, and enhance exercise performance.
Overall, L-Histidine is a valuable food additive that provides a range of benefits to the food industry. It is commonly used in processed foods to enhance their flavor and improve their nutritional value, and is generally safe for consumption in small amounts. As with any food additive or dietary supplement, it is important to use L-Histidine in moderation and in accordance with industry guidelines to ensure its safety and efficacy.
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