L-Histidine Methyl Ester Dihydrochloride
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Methyl L-histidinate dihydrochloride
Structure
CAS No. 7389-87-9 Boiling Point (℃) 368.2ºC at 760 mmHg
Molecular Weight 242.103 Melting Point (℃) 207 °C (dec.)(lit.)
Density N/A Vapor Specific Gravity N/A
Molecular Formula C7H13Cl2N3O2 Flash Point (℃) 176.5ºC
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description Methyl L-histidinate dihydrochloride is a histidine derivative[1].
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References [1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
Synonyms
L-Histidine, methyl ester, dihydrochloride
H-L-His-OMe dihydrochloride
L-Histidine Methyl Ester 2HCl
H-His-OMe dihydrochloride
EINECS 230-973-9
HISTIDINE-OME 2 HCL
H-His-OMe.2HCI
H-L-HIS-OME 2HCL
L-Histidine methyl e
L-HISTIDINE METHYL ESTER DIHCL
H-His-OMe.2HCl
H-His-OMe,2HCl
MethylL-histidinatedihydrochloride
Product Description
Introduction: L-Histidine Methyl Ester Dihydrochloride is a chemical compound derived from L-histidine, an essential amino acid with important physiological functions in the human body. This product possesses unique properties and potential applications, making it valuable in various industries such as pharmaceuticals, food, and research.

Raw Materials: L-Histidine Methyl Ester Dihydrochloride is synthesized using high-quality raw materials, including L-histidine and dihydrochloride. L-histidine is obtained through appropriate chemical reactions or enzymatic methods, ensuring its purity and effectiveness. Dihydrochloride is a compound that provides stability and facilitates the handling and formulation of the final product.

Production Process: The production of L-Histidine Methyl Ester Dihydrochloride involves controlled steps to maintain consistent product quality. L-histidine is first obtained from the appropriate source and then reacted with dihydrochloride under specific conditions. The reaction mixture undergoes purification techniques such as filtration, crystallization, and drying, resulting in a white crystalline powder as the final product.

Market Trends: L-Histidine Methyl Ester Dihydrochloride has gained significant attention in the pharmaceutical, food, and research industries due to its potential applications. In the pharmaceutical sector, it serves as a building block in the synthesis of drugs targeting various health conditions, including allergies, inflammation, and neurological disorders. In the food industry, L-Histidine Methyl Ester Dihydrochloride is used as a flavor enhancer and a precursor in the production of food additives. In research, it is utilized as a tool for studying protein structure, enzymatic reactions, and cell signaling pathways. The market demand for this product is driven by the growing interest in amino acids and their role in human health, nutrition, and scientific advancements.

Amino Acid Status: L-Histidine Methyl Ester Dihydrochloride offers unique advantages as an amino acid derivative. L-histidine is an essential amino acid that plays a vital role in protein synthesis, neurotransmission, immune function, and histamine regulation. As a methyl ester, L-Histidine Methyl Ester Dihydrochloride exhibits improved stability and solubility, enhancing its utility in various applications. Its availability as a supplement allows for convenient incorporation into formulations aimed at promoting health, supporting neurotransmitter balance, and advancing scientific research.

Conclusion: L-Histidine Methyl Ester Dihydrochloride is a valuable chemical compound with diverse applications in the pharmaceutical, food, and research industries. Its synthesis from high-quality raw materials and stringent production processes ensure consistent product quality. The market demand for this product is expected to continue growing due to its unique properties and potential applications in pharmaceuticals, food formulations, and scientific research. With its various applications and potential contributions to health, nutrition, and scientific advancements, L-Histidine Methyl Ester Dihydrochloride offers a valuable option for formulation and application in different industries, providing a convenient means to support health and wellness goals, enhance food products, and drive scientific research forward.

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