L-Aspartic Acid
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names L-Aspartic acid
Structure
CAS No. 56-84-8 Boiling Point (℃) 264.1±30.0 °C at 760 mmHg
Molecular Weight 133.103 Melting Point (℃) >300 °C (dec.)(lit.)
Density 1.5±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C4H7NO4 Flash Point (℃) 113.5±24.6 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description L-Aspartic acid is is an amino acid, shown to be a suitable prodrug for colon-specific drug deliverly.
Target Human Endogenous Metabolite
In Vitro L-Aspartic acid is shown to be a suitable prodrug for colon-specific drug deliverly[1]. L-[3H]Asp remaining in the brain at 5 min is increased by 206 and 178% by preadministration of 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, whereas 100 mM D-Asp does not affect L-[3H]Asp efflux transport. That value for L-[3H]Glu at 20 min is increased by 145 and 156% by coadministration with 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, but not by D-Asp. It is interesting that the apparent efflux rate of L-Aspartic acid across the BBB is sevenfold faster than that of L-Glu[2].
References [1]. Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406.
[2]. Hosoya K, et al. Blood-brain barrier produces significant efflux of L-aspartic acid but not D-aspartic acid: in vivo evidence using the brain efflux index method. J Neurochem. 1999 Sep;73(3):1206-11.
Synonyms
asparagic acid
1-amino-1,2-carboxyethane
δ-aspartic acid
d-Asp
QVYZ1VQ &&D or R Form
(-)-Aspartic acid
(2R)-2-Aminosuccinic acid
MFCD00002616
(2R)-2-aminobutanedioic acid
hydrogen D-aspartate
L-Asparticacid
Product Description
L-Aspartic acid is a non-essential amino acid that is widely used in the food industry as a flavor enhancer, acidity regulator, and nutrient supplement. As a food-grade product, it is produced through a fermentation process using natural substrates.
One of the key properties of L-Aspartic acid is its ability to enhance the umami flavor of foods, which is one of the five basic tastes. It is commonly used in savory products such as soups, broths, sauces, and snacks to improve their overall taste and flavor. In addition, L-Aspartic acid is also used as an acidity regulator in various food products, including carbonated beverages, fruit juices, and dairy products. It helps to maintain the pH balance of these products and prevent spoilage.
Another important application of L-Aspartic acid is its use as a nutrient supplement. It is an important precursor for the synthesis of other amino acids, such as L-methionine and L-threonine, which are essential for protein synthesis in the body. As a result, L-Aspartic acid is often added to sports drinks, energy bars, and other nutritional supplements to support muscle growth and recovery.
L-Aspartic acid is generally recognized as safe (GRAS) by the United States Food and Drug Administration (FDA) and is approved for use in food products in many countries around the world. It is available in both powder and granular forms, making it easy to incorporate into a variety of food and beverage applications.
Overall, L-Aspartic acid is a versatile and widely used food-grade product that provides a range of benefits to the food industry. Its unique flavor-enhancing properties, acidity regulation capabilities, and nutritional benefits make it an essential ingredient in many food products today.
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