L(+)-Arginine

Specifications

N/A

Packing & Storage

Packing
Storage	Powder -20°C 3 years 4°C 2 years；In solvent -80°C 6 months, -20°C 1 month
Shipping	Room temperature in continental US; may vary elsewhere

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General Information

Chemical & Physical Properties

Safety Information

Synthetic Route

Biological Activity

Common Names	L(+)-Arginine
Structure
CAS　No.	74-79-3	Boiling Point (℃)	367.6±52.0 °C at 760 mmHg
Molecular Weight	174.201	Melting Point (℃)	222 °C (dec.)(lit.)
Density	1.5±0.1 g/cm3	Vapor Specific Gravity	N/A
Molecular Formula	C6H14N4O2	Flash Point (℃)	176.1±30.7 °C
Solubility	N/A	Autoignition Temperature (℃)	N/A

Personal Protective Equipment		Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes		T+:Very toxic
Safety Phrases		S1-S28-S45
RIDADR		NONH for all modes of transport
WGK Germany		3
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Cough. Sore throat.	Use local exhaust or breathing protection.	Fresh air, rest.
Skin	Redness. Burning sensation. Itching.	Protective gloves.	Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes	Redness. Pain.	Wear safety goggles.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Abdominal pain. Nausea. Vomiting.	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.

Description	L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.Target: OthersL-Arginine is an α-amino acid. It was first isolated in 1886. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice.
Target	Human Endogenous Metabolite
In Vitro	DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References	[1]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45. [2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12. [3]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17.

Synonyms

L-Arginine
L-ornithine, N-(diaminomethylene)-
MFCD00002635
H-L-ARG-OH
L-Argnie
(L)-Arginine
L-ARG-OH
L-arginie
AGRININE
arginine
L(+)-Arginine

Product Description

Product Introduction of L(+)-Arginine from a Food Grade and Performance Perspective
L(+)-Arginine is a non-essential amino acid that is important for protein synthesis and various metabolic processes in the body. It is a popular ingredient in many dietary supplements and functional foods due to its potential health benefits, including improved cardiovascular function, immune system support, and enhanced athletic performance.
From a food grade perspective, L(+)-Arginine is considered safe for human consumption by the Food and Drug Administration (FDA) and the European Food Safety Authority (EFSA). It can be used as a food additive in a wide range of products, including beverages, confectionery, bakery, and dairy products. However, it is important to note that excessive consumption of L(+)-Arginine may cause adverse effects, such as gastrointestinal discomfort and diarrhea.
L(+)-Arginine also has several performance benefits that make it a popular ingredient in sports nutrition products. It is a precursor to nitric oxide (NO), a molecule that promotes vasodilation and improves blood flow to the muscles during exercise. This can lead to improved endurance, increased muscle pumps, and reduced fatigue.
Additionally, L(+)-Arginine may also help to increase growth hormone levels, which can lead to increased muscle mass and reduced body fat. It has also been shown to enhance post-exercise recovery and reduce muscle soreness.
In summary, L(+)-Arginine is a versatile and beneficial ingredient that can be used in a wide range of food and supplement products. It is generally considered safe for human consumption and has numerous performance benefits that make it a popular ingredient in sports nutrition products. However, it is important to consume L(+)-Arginine in moderation and under the guidance of a healthcare professional.

Pharmaceutical Grade	Protecting Reagent	Protected Amino Acids
Food Grade	Feed Grade	Amino Acid Salts And Derivatives

Pharmaceutical Grade	Protecting Reagent	Protected Amino Acids
Food Grade	Feed Grade	Amino Acid Salts And Derivatives