Glycyl-L-Histidyl-L-Lysine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Copper Peptide;Gly-His-Lys
Structure
CAS No. 49557-75-7 Boiling Point (℃) 831.0±65.0 °C at 760 mmHg
Molecular Weight 340.378 Melting Point (℃) N/A
Density 1.3±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C14H24N6O4 Flash Point (℃) 456.4±34.3 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description Glycyl-L-histidyl-L-lysine is a tripeptide consisting of glycine, L-histidine and L-lysine residues joined in sequence. Glycyl-L-histidyl-L-lysine is a hepatotropic immunosuppressor and shows anxiolytic effect. Glycyl-L-histidyl-L-lysine and its copper complexes show good skin tolerance[1][2][3].
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro Glycyl-L-histidyl-L-lysine and its copper complexes and saccharomyces/copper ferment on secretion of pro-inflammatory IL-6 in normal human dermal fibroblasts NHDF cell line[1]. Glycyl-L-histidyl-L-lysine and its copper complexes decreases TNF-α-dependent IL-6 secretion in fibroblasts[1].
References [1]. Arkadiusz Gruchlik, et al. Effect of Gly-Gly-His, Gly-His-Lys and their copper complexes on TNF-alpha-dependent IL-6 secretion in normal human dermal fibroblasts. Acta Pol Pharm. 2012 Nov-Dec;69(6):1303-6.
[2]. M Yu Smakhtin, et al. Tripeptide Gly-His-Lys is a hepatotropic immunosuppressor. Bull Exp Biol Med. 2002 Jun;133(6):586-7.
[3]. I Bobyntsev, et al. Anxiolytic effects of Gly-His-Lys peptide and its analogs. Bull Exp Biol Med. 2015 Apr;158(6):726-8.
Synonyms
Liver growth factor
Gly-L-His-L-Lys
Liver cell growth factor
L-Lysine, glycyl-L-histidyl-
Glycyl-L-Histidyl-L-Lysine
GHK Cu Copper Peptide
H-Gly-His-Lys-OH
glycyl-histidyl-lysine
ghk
Copper Peptide
Ahk-cu
Growth-modulating peptide
Gly-His-Lys-Cu
Copper Peptide (GHK-Cu)
Product Description
Introduction: Glycyl-L-Histidyl-L-Lysine is a significant chemical compound with diverse applications in the chemical industry. This product introduction aims to provide an overview of Glycyl-L-Histidyl-L-Lysine, covering its raw materials, production process, market trends, and the current status of amino acids in the industry.

Raw Materials: Glycyl-L-Histidyl-L-Lysine is synthesized using glycine, L-histidine, and L-lysine as the primary raw materials. Glycine, L-histidine, and L-lysine serve as the precursors for the synthesis of Glycyl-L-Histidyl-L-Lysine.

Production Process: The production process of Glycyl-L-Histidyl-L-Lysine involves the following steps:
Step 1: Coupling - Glycine, L-histidine, and L-lysine are coupled using suitable coupling agents or reagents to form Glycyl-L-Histidyl-L-Lysine. The coupling reaction is typically carried out in an appropriate solvent under controlled conditions.

Step 2: Purification - The resulting Glycyl-L-Histidyl-L-Lysine is purified and refined using techniques such as filtration, chromatography, or crystallization to achieve the desired level of purity.

Market Trends: The market demand for Glycyl-L-Histidyl-L-Lysine has been increasing due to its diverse applications across various industries. Here are some key market trends:
Pharmaceuticals: Glycyl-L-Histidyl-L-Lysine finds applications in the pharmaceutical industry. It can be used as a peptide-based drug or as a component in drug formulations targeting specific therapeutic areas. Peptide-based drugs have gained significant attention due to their high specificity and targeted activity.

Cosmetics: Glycyl-L-Histidyl-L-Lysine is also used in the cosmetic industry. It can be incorporated into skincare products for its potential anti-aging and skin-conditioning properties. Peptides are known for their ability to promote collagen synthesis and improve skin elasticity.

Current Status of Amino Acids: Amino acids play a crucial role in various sectors, including pharmaceuticals, cosmetics, and biotechnology. They are the building blocks of proteins and have diverse functions in living organisms. Glycine, L-histidine, and L-lysine are among the important amino acids used in various industries.

Conclusion: Glycyl-L-Histidyl-L-Lysine, synthesized by coupling glycine, L-histidine, and L-lysine, holds significant value in the chemical industry. Its production involves the coupling of the amino acids, followed by purification. The market demand for Glycyl-L-Histidyl-L-Lysine is driven by its applications in the pharmaceutical and cosmetic industries. Amino acids continue to be essential components in various industries, contributing to advancements in chemical applications and product development.

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