Fluorenylmethoxycarbonyl Chloride
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Fluorenylmethoxycarbonyl chloride
Structure
CAS No. 28920-43-6 Boiling Point (℃) 393.9±11.0 °C at 760 mmHg
Molecular Weight 258.7 Melting Point (℃) 62-64 °C(lit.)
Density 1.3±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C15H11ClO2 Flash Point (℃) 143.6±11.4 °C
Solubility dioxane: 0.1 g/mL, clear, colorless Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description DL-Lysine (Lysine) is an α-amino acid that is used in the biosynthesis of proteins.
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Nguyen TV, et al. PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange. Pharm Res. 2007 Feb;24(2):353-60.
Synonyms
9-Fluorenylmethoxycarbonyl chloride
9-Fluorenylmethyl Chloroformate [N-Protecting Agent
9-fluorenylmethyl chlorocarbonate
9-Fluorenylmethyl Chloroformate Fmoc chloride
(9H-Fluoren-9-yl)methyl chloroformate
Fmoc-Cl
9H-fluoren-9-ylmethyl chloroformate
9-Fluorenylmethyl chloroformate
Fmoc chloroformate
Fmoc chloride
Product Description
Fluorenylmethoxycarbonyl chloride, also known as Fmoc-Cl, is a chemical compound that belongs to the family of amino acid protecting groups. It is widely used as a reagent for the synthesis of peptides and proteins, as it can be used to protect the amino group of an amino acid. Fmoc-Cl is a popular choice for amino acid protection due to its stability and ease of use. In this article, we will explore the production and application of Fmoc-Cl and its market industry development.

Production of Fmoc-Cl involves the reaction of fluorenylmethanol with phosgene, resulting in the formation of Fmoc-Cl. The process is highly efficient and yields a high purity product. Fmoc-Cl is commonly available in the form of a white to off-white crystalline powder with a purity of over 99%. It is generally stored in a cool, dry place away from direct sunlight and moisture to maintain its stability.

Fmoc-Cl has a wide range of applications in the field of peptide synthesis. It is used as a protecting group for the amino group of an amino acid during peptide synthesis, which helps to prevent unwanted reactions with other reagents. Fmoc-Cl is also used in the synthesis of peptides and proteins using solid-phase peptide synthesis (SPPS) techniques. In addition, Fmoc-Cl is used in the production of Fmoc-protected amino acids, which are widely used in peptide synthesis. These amino acids are crucial building blocks in the production of peptide drugs and other biologically active compounds.

The market industry for Fmoc-Cl is expected to grow significantly in the coming years, driven by the increasing demand for peptide and protein-based drugs. Peptides and proteins have gained significant attention in the pharmaceutical industry due to their high specificity and efficacy. Fmoc-Cl is an essential reagent in the production of these biologically active compounds. The rise in demand for peptide and protein-based drugs is expected to drive the growth of the Fmoc-Cl market.

In addition, the increasing use of SPPS techniques in drug discovery and development is also expected to drive the demand for Fmoc-Cl. SPPS techniques offer several advantages, such as high yields, low production costs, and the ability to produce large quantities of peptides with high purity. The use of Fmoc-Cl in SPPS techniques is expected to increase in the future, further driving the growth of the Fmoc-Cl market.

In conclusion, Fmoc-Cl is a crucial reagent in the production of peptides and proteins, and its use is expected to increase significantly in the coming years. The rise in demand for peptide and protein-based drugs, coupled with the increasing use of SPPS techniques, is expected to drive the growth of the Fmoc-Cl market.

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