D-Methionine

Specifications

N/A

Packing & Storage

Packing
Storage	Powder -20°C 3 years 4°C 2 years；In solvent -80°C 6 months, -20°C 1 month
Shipping	Room temperature in continental US; may vary elsewhere

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General Information

Chemical & Physical Properties

Safety Information

Synthetic Route

Biological Activity

Common Names	D-Methionine
Structure
CAS　No.	348-67-4	Boiling Point (℃)	306.9±37.0 °C at 760 mmHg
Molecular Weight	149.211	Melting Point (℃)	273-275ºC
Density	1.2±0.1 g/cm3	Vapor Specific Gravity	N/A
Molecular Formula	C5H11NO2S	Flash Point (℃)	139.4±26.5 °C
Solubility	N/A	Autoignition Temperature (℃)	N/A

Personal Protective Equipment		Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes		T+:Very toxic
Safety Phrases		S1-S28-S45
RIDADR		NONH for all modes of transport
WGK Germany		3
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Cough. Sore throat.	Use local exhaust or breathing protection.	Fresh air, rest.
Skin	Redness. Burning sensation. Itching.	Protective gloves.	Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes	Redness. Pain.	Wear safety goggles.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Abdominal pain. Nausea. Vomiting.	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.

Description	Methionine (MRX-1024) is an effective chemoprotective agent which can also inhibit the neuronal activity through GABAA receptor activation.
Target	GABAA receptor[1]
In Vitro	The incubation of human plasma with Methionine (D-methionine) and CP leads to the formation of a Pt-D-methionine complex independent of the order of addition. In plasma, an early CP hydrolysis product reacts with Methionine to form a 1:1 complex that is followed by the formation of a 2:1 compound at a later time point. The formation of these Pt-D-methionine species plays an important role in the processes by which Methionine protects mammalian organisms against CP-induced toxicities[2].
References	[1]. Wu C, et al. Antioxidants L-carnitine and D-methionine modulate neuronal activity through GABAergic inhibition. J Neural Transm (Vienna). 2014 Jul;121(7):683-93. [2]. Sooriyaarachchi M, et al. Chemoprotection by D-methionine against cisplatin-induced side-effects: insight from in vitrostudies using human plasma. Metallomics. 2014 Mar;6(3):532-41. [3]. Hinduja S, et al. D-methionine protects against cisplatin-induced neurotoxicity in the hippocampus of the adult rat. Neurotox Res. 2015 Apr;27(3):199-204.

Synonyms

EINECS 253-012-5
Bishydroxyethyldithiocarbamicacidzincsalt
L-Asparticacidzincsalt
Zinc (2R)-2-amino-3-carboxypropanoate (2S)-2-amino-3-carboxypropanoate (1:1:1)
MFCD00239525
L-Aspartic acid zinc salt
Zinc aspartate
zinc bisaspartate
R-Methionine
(R)-2-amino-4-(methylthio)butanoic acid
Methionine, D-
D-Methionin
d-Met
(2R)-2-amino-4-(methylsulfanyl)butanoic acid
(R)-methionine
D-Methionine
(R)-2-Amino-4-(methylmercapto)butyric acid (D-2-Amino-4-(methylthio)butanoic acid
EINECS 206-483-6
(2R)-2-amino-4-methylsulfanylbutanoic acid
H-D-Met-OH
MFCD00002622
H-D-Met-OEt.HCl
MRX-1024

Product Description

D-methionine is a non-essential amino acid that has a variety of uses in the medical industry. In this analysis, we will explore the uses of D-methionine in medicine, the upstream and downstream industries involved in its production, the current market trends, and the major chemical suppliers.
Uses of D-methionine in medicine:
D-methionine has been shown to have a variety of potential medical uses. It is commonly used as an ingredient in chelation therapy, a treatment used to remove heavy metals from the body. It is also used in the treatment of liver disease, as it has been shown to have a protective effect on the liver. Additionally, D-methionine has been used to reduce inflammation and as an antioxidant.
Upstream and downstream industries:
The production of D-methionine involves a number of upstream and downstream industries. The primary raw material used in the production of D-methionine is DL-methionine, which is produced through the fermentation process. Other upstream industries involved in the production of D-methionine include the production of amino acids and other raw materials used in the fermentation process.
Downstream industries include the production of various pharmaceuticals that use D-methionine as an ingredient. These include chelation therapy drugs, liver disease treatments, and anti-inflammatory medications. The downstream industry also includes the production of food supplements that contain D-methionine.
Market trends:
The market for D-methionine is expected to grow significantly in the coming years. This growth is primarily driven by the increasing demand for chelation therapy drugs and liver disease treatments. Additionally, the use of D-methionine as an antioxidant and anti-inflammatory agent is also expected to contribute to the growth of the market.
Chemical suppliers:
There are a number of chemical suppliers that produce and sell D-methionine. Some of the major suppliers include Ajinomoto, Evonik, and Prinova. These companies produce D-methionine using various methods, including fermentation and chemical synthesis.
Conclusion:
D-methionine is a valuable ingredient in the medical and food supplement industries. Its potential benefits make it an important raw material for the production of a number of pharmaceutical products. The growing demand for chelation therapy drugs and liver disease treatments is expected to drive the growth of the market in the coming years.

Pharmaceutical Grade	Protecting Reagent	Protected Amino Acids
Food Grade	Feed Grade	Amino Acid Salts And Derivatives

Pharmaceutical Grade	Protecting Reagent	Protected Amino Acids
Food Grade	Feed Grade	Amino Acid Salts And Derivatives