D-Leucine

Specifications

N/A

Packing & Storage

Packing
Storage	Powder -20°C 3 years 4°C 2 years；In solvent -80°C 6 months, -20°C 1 month
Shipping	Room temperature in continental US; may vary elsewhere

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General Information

Chemical & Physical Properties

Safety Information

Synthetic Route

Biological Activity

Common Names	D-Leucine
Structure
CAS　No.	328-38-1	Boiling Point (℃)	225.8±23.0 °C at 760 mmHg
Molecular Weight	131.173	Melting Point (℃)	> 300ºC
Density	1.0±0.1 g/cm3	Vapor Specific Gravity	N/A
Molecular Formula	C6H13NO2	Flash Point (℃)	90.3±22.6 °C
Solubility	N/A	Autoignition Temperature (℃)	N/A

Personal Protective Equipment		Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes		T+:Very toxic
Safety Phrases		S1-S28-S45
RIDADR		NONH for all modes of transport
WGK Germany		3
	SYMPTOMS	PREVENTION	FIRST AID
Inhalation	Cough. Sore throat.	Use local exhaust or breathing protection.	Fresh air, rest.
Skin	Redness. Burning sensation. Itching.	Protective gloves.	Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes	Redness. Pain.	Wear safety goggles.	First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion	Abdominal pain. Nausea. Vomiting.	Do not eat, drink, or smoke during work. Wash hands before eating.	Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.

Description	D-Leucine is a more potent anti-seizure agent than L-leucine. D-leucine potently terminates seizures even after the onset of seizure activity. D-leucine, but not L-leucine, reduces long-term potentiation but had no effect on basal synaptic transmission in vitro[1].
Target	Human Endogenous Metabolite
In Vitro	In a screen of candidate neuronal receptors, D-leucine failed to compete for binding by cognate ligands, potentially suggesting a novel target. Even at low doses, D-leucine suppressed ongoing seizures at least as effectively as diazepam but without sedative effects. These studies raise the possibility that D-leucine may represent a new class of anti-seizure agents, and that D-leucine may have a previously unknown function in eukaryotes[1].
References	[1]. Xiaoyu Cao, et al. Combination of PARP Inhibitor and Temozolomide to Suppress Chordoma Progression. J Mol Med (Berl). 2019 Aug;97(8):1183-1193

Synonyms

leucine
D-Leucine
MFCD00063088
(R)-2-Amino-4-methylpentanoic acid
(2R)-2-amino-4-methylpentanoic acid
ent-1
H-Leu-OH
D-Homo-valine
D-2-Amino-4-methylvaleric acid
H-D-Leu-OH
(R)-2-Amino-4-methyl-pentanoic acid
Leucine, D-
EINECS 206-327-7
D-2-Amino-4-methylpentanoicacid

Product Description

D-leucine is a non-essential amino acid that is commonly used in the pharmaceutical industry for its various benefits. In this analysis, we will look at the uses of D-leucine in medicine, its upstream and downstream industries, market trends, and major chemical suppliers.
Uses of D-leucine in medicine:
D-leucine is used as an ingredient in a number of pharmaceutical products. It has been shown to improve insulin sensitivity in patients with type 2 diabetes, and it is also used in the production of ACE inhibitors, which are used to treat high blood pressure. Additionally, D-leucine has been used to improve muscle growth in athletes and as a treatment for liver disease.
Upstream and downstream industries:
The production of D-leucine involves a number of upstream and downstream industries. The primary raw material used in the production of D-leucine is L-leucine, which is produced by fermentation. Other upstream industries involved in the production of D-leucine include the production of amino acids and other raw materials used in the fermentation process.
Downstream industries include the production of various pharmaceuticals that use D-leucine as an ingredient. These include insulin sensitizers, ACE inhibitors, and muscle growth supplements. The downstream industry also includes the production of food supplements that contain D-leucine.
Market trends:
The market for D-leucine is expected to grow significantly in the coming years. This growth is primarily driven by the increasing demand for D-leucine in the pharmaceutical industry. Additionally, the use of D-leucine in the food supplement industry is also expected to contribute to the growth of the market.
Chemical suppliers:
There are a number of chemical suppliers that produce and sell D-leucine. Some of the major suppliers include Kyowa Hakko Bio, Ajinomoto, and Evonik. These companies produce D-leucine using various methods, including fermentation and chemical synthesis.
Conclusion:
In conclusion, D-leucine is a valuable ingredient in the pharmaceutical and food supplement industries. Its various benefits make it an important raw material for the production of a number of pharmaceutical products. The growing demand for D-leucine in these industries is expected to drive the growth of the market in the coming years.

Pharmaceutical Grade	Protecting Reagent	Protected Amino Acids
Food Grade	Feed Grade	Amino Acid Salts And Derivatives

Pharmaceutical Grade	Protecting Reagent	Protected Amino Acids
Food Grade	Feed Grade	Amino Acid Salts And Derivatives