D-Histidine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names D-Histidine
Structure
CAS No. 351-50-8 Boiling Point (℃) 458.9±35.0 °C at 760 mmHg
Molecular Weight 155.155 Melting Point (℃) 287ºC
Density 1.4±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C6H9N3O2 Flash Point (℃) 231.3±25.9 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description D-Histidine is an enantiomer of L-histidine (HY-N0832). L-Histidine is an essential amino acid for infants. L-Histidine is an inhibitor of mitochondrial glutamine transport[1].
Target Human Endogenous Metabolite
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Bou Zeidan M, et al. L-histidine inhibits biofilm formation and FLO11-associated phenotypes in Saccharomyces cerevisiae flor yeasts. PLoS One. 2014 Nov 4;9(11):e112141.
Synonyms
D-Histidine
(R)-2-Amino-3-(1H-imidazol-4-yl)propanoic acid
H-D-His-OH
Histidine
EINECS 206-513-8
hydrogen D-histidinate
MFCD00065963
D-His-OH
(2R)-2-amino-3-(1H-imidazol-5-yl)propanoic acid
Product Description
D-histidine is an amino acid that is widely used in the pharmaceutical, food, and cosmetic industries. In this product analysis, we will explore the medical uses, upstream and downstream industries, market trends, and key suppliers of D-histidine.
Medical Uses:
D-histidine is a non-essential amino acid that is used in the human body to produce histamine, a neurotransmitter that is essential for the immune system, digestion, and sleep-wake cycles. Additionally, D-histidine has been found to have antioxidant properties and can help regulate blood pressure. It is also used in the pharmaceutical industry as a precursor for the synthesis of histidine-containing peptides and proteins.
Upstream and Downstream Industries:
D-histidine is mainly produced by chemical synthesis. The upstream raw materials include imidazole, which is synthesized from glyoxal and ammonia. The downstream industries that use D-histidine include the production of histidine-containing peptides and proteins, which are used in pharmaceuticals, nutraceuticals, and functional foods.
Market Trends:
The global market for D-histidine is growing due to its increasing use in pharmaceuticals and nutraceuticals. The rise in demand for histidine-containing peptides and proteins is driving the growth of the D-histidine market. Additionally, the growing awareness of the benefits of amino acids for maintaining a healthy lifestyle is also contributing to the market growth. Key Suppliers:
Some of the key suppliers of D-histidine include Ajinomoto Co., Inc., Kyowa Hakko Bio Co., Ltd., and Sigma-Aldrich Corporation. These suppliers offer high-quality D-histidine products that meet the stringent quality standards of the pharmaceutical, food, and cosmetic industries. They also provide technical support and custom synthesis services to meet the specific requirements of their customers.
In conclusion, D-histidine is an important amino acid that is used in a wide range of industries, including pharmaceuticals, nutraceuticals, and functional foods. Its medical uses include producing histamine and regulating blood pressure. The D-histidine market is growing due to the increasing demand for histidine-containing peptides and proteins and the growing awareness of the benefits of amino acids. Key suppliers such as Ajinomoto Co., Inc., Kyowa Hakko Bio Co., Ltd., and Sigma-Aldrich Corporation provide high-quality D-histidine products and technical support to their customers.
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