D-Asparagine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names D-Asparagine
Structure
CAS No. 2058-58-4 Boiling Point (℃) 438.0±40.0 °C at 760 mmHg
Molecular Weight 132.118 Melting Point (℃) 280ºC (dec.)
Density 1.4±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C4H8N2O3 Flash Point (℃) 218.7±27.3 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description D-Asparagine (H-D-Asn-OH) is a competitive inhibitor of L-Asparagine hydrolysis with a Ki value of 0.24 mM. D-Asparagine is a source of nitrogen for yeast strains. D-Asparagine is a good substrate for the external yeast asparaginase but is a poor substrate for the internal enzyme[1].
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. P C Dunlop, et al. Utilization of D-asparagine by Saccharomyces Cerevisiae. J Bacteriol. 1976 Mar;125(3):999-1004.
Synonyms
D-Asparagine
H-D-Asn-OH·H2O
D-b-Asparagine
EINECS 218-163-3
Asparagine, DL-
H-D-Asn-OH.H2O
Aspartic Acid b-Amide
2-Aminosuccinamic acid
H-D-Asn-OH
(R)-2,4-Diamino-4-oxobutanoic acid
a-Aminosuccinamic acid
(2R)-2,4-diamino-4-oxobutanoic acid
Asparagine D-form
Product Description
D-Asparagine is a non-essential amino acid that is widely used in the pharmaceutical industry for various applications. In this product analysis, we will discuss the medical uses, upstream and downstream of D-Asparagine, market trends, and chemical suppliers' perspectives.
Medical Uses: D-Asparagine is commonly used as a nutritional supplement for patients suffering from chronic kidney disease, as it can help to maintain proper nitrogen balance in the body. It is also used in the formulation of parenteral nutrition products for individuals who cannot consume food orally. Moreover, D-Asparagine has also been studied for its potential therapeutic applications in treating neurological disorders and cancer.
Upstream and Downstream: The production of D-Asparagine usually starts from L-Asparagine, which is converted to D-Asparagine by the action of specific enzymes. The upstream materials required for its production include L-Asparagine, enzymes, and other chemicals. The downstream products include pharmaceutical intermediates, parenteral nutrition products, and other nutraceutical products.
Market Trends: The global market for D-Asparagine is expected to grow significantly in the coming years due to the increasing demand for parenteral nutrition products and dietary supplements. The pharmaceutical industry is the largest consumer of D-Asparagine, and the demand for this amino acid is driven by the increasing prevalence of chronic kidney disease and cancer. In addition, the use of D-Asparagine in the food and beverage industry is also expected to increase due to its potential benefits as a natural flavor enhancer.
Chemical Suppliers' Perspectives: There are several chemical suppliers of D-Asparagine worldwide, including Ajinomoto Co. Inc., Kyowa Hakko Bio Co. Ltd., and Sigma-Aldrich Co. LLC. These suppliers offer D-Asparagine in different grades and quantities to meet the diverse needs of their customers. They also provide technical support and custom synthesis services to their clients, ensuring that their products meet the highest quality standards.
In conclusion, D-Asparagine is a versatile amino acid that has various applications in the pharmaceutical, nutraceutical, and food industries. As the demand for parenteral nutrition products and dietary supplements increases, the market for D-Asparagine is expected to grow, presenting opportunities for chemical suppliers and manufacturers.
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