D-Alanine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names D-Alanine
Structure
CAS No. 338-69-2 Boiling Point (℃) 212.9±23.0 °C at 760 mmHg
Molecular Weight 89.093 Melting Point (℃) 278-282ºC
Density 1.2±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C3H7NO2 Flash Point (℃) 82.6±22.6 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description D-Alanine is a weak GlyR (inhibitory glycine receptor) and PMBA agonist, with an EC50 of 9 mM for GlyR.
Target GlyR:9 mM (EC50)
PMBA
Human Endogenous Metabolite
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Schmieden V, et al. Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds. Mol Pharmacol. 1995 Nov;48(5):919-27.
[2]. Saitoh T, et al. A novel antagonist, phenylbenzene omega-phosphono-alpha-amino acid, for strychnine-sensitive glycine receptors in the rat spinal cord. Br J Pharmacol. 1994 Sep;113(1):165-70.
Synonyms
(R,S)-Alanine
(±)-Alanine
(R)-2-aminopropanoic acid
D-a-Alanine
Alanine, D-
Propanoic acid, 2-amino-
(±)-2-Aminopropionic acid
2-amino-propanoic acid
D-α-aminopropionic acid
Alanine,D
Alanine D-
DL-2-aminopropionic acid
(2R)-2-aminopropanoic acid
α-Aminopropanoic acid
D-Alanine
2-Aminopropanoic acid
Product Description
D-alanine is a non-proteinogenic amino acid that is commonly used in the pharmaceutical industry for a variety of purposes. From a market perspective, D-alanine has experienced steady growth in demand in recent years, driven by its use in various drug formulations.
One of the primary uses of D-alanine is as a building block for peptide and protein synthesis. It is a key component in the production of antibiotics, such as cycloserine, which is used to treat tuberculosis. In addition, D-alanine is also used in the production of antiviral and anticancer drugs.
In the cosmetic industry, D-alanine is also used as a skin conditioning agent, due to its ability to promote hydration and elasticity. This has led to an increase in demand for D-alanine in the skincare industry, with many companies incorporating it into their products.
In terms of market trends, the demand for D-alanine has been steadily increasing in recent years. This can be attributed to a growing interest in natural and organic ingredients in pharmaceutical and cosmetic products. D-alanine is a naturally occurring amino acid, which makes it an attractive ingredient for these markets.
Furthermore, the COVID-19 pandemic has also contributed to the demand for D-alanine, as it is used in the production of drugs that are being developed to combat the virus. This has led to an increase in demand for D-alanine from pharmaceutical companies worldwide.
Overall, the market for D-alanine is expected to continue to grow in the coming years. As the demand for natural and organic ingredients in pharmaceutical and cosmetic products continues to increase, D-alanine is likely to become an increasingly popular ingredient. Additionally, the ongoing research into the potential use of D-alanine in the treatment of COVID-19 will also drive demand for this amino acid in the pharmaceutical industry.
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