BOC-β-Alanine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Boc-beta-alanine
Structure
CAS No. 3303-84-2 Boiling Point (℃) 320.9±25.0 °C at 760 mmHg
Molecular Weight 189.209 Melting Point (℃) 76-78 °C
Density 1.1±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C8H15NO4 Flash Point (℃) 147.9±23.2 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description Boc-β-Ala-OH is an alanine derivative[1].
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References [1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1095.
Synonyms
N-(tert-Butyloxycarbonyl)-l-alanine
(2S)-2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid
N-{[(2-Methyl-2-propanyl)oxy]carbonyl}alanine
N-(tert-Butoxycarbonyl)-L-alanine
EINECS 221-979-2
N-tert-butyloxycarbonyl-(S)-alanine
Boc-Beta-Ala-OH
3-(tert-Butoxycarbonylamino)-propanoic acid
Boc-β-Ala-OH
3-tert-Butoxycarbonylaminopropionic acid
3-[[(1,1-Dimethylethoxy)carbonyl]amino]-propanoic acid
l-Boc-alanine
N-[t-Butoxycarbonyl]-l-alanine
L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-
Boc-beta-alanine
Product Description
Introduction: BOC-β-Alanine is a vital amino acid protecting agent widely used in peptide synthesis. With its exceptional properties and compatibility with peptide assembly techniques, BOC-β-Alanine enables the efficient synthesis of peptides containing β-alanine residues. Its high purity, reliability, and versatility make it an indispensable tool for chemists and researchers involved in peptide synthesis projects.

Product Features: High Purity: BOC-β-Alanine is manufactured with meticulous attention to purity, ensuring minimal impurities. Its superior quality guarantees the synthesis of peptides with excellent purity and structural integrity.

Effective Protecting Group: BOC-β-Alanine serves as a reliable protecting group for the amino group of β-alanine, preventing unwanted reactions during peptide chain elongation. It selectively shields the amino group, allowing controlled incorporation of β-alanine into peptides.

Versatile Applications: BOC-β-Alanine finds extensive use in the synthesis of peptides with β-alanine residues. Peptides containing β-alanine exhibit unique properties, such as altered charge, increased hydrophobicity, and enhanced stability, making them valuable in drug discovery, peptide-based therapeutics, and biochemical research.

Applications: Peptide-Based Therapeutics: BOC-β-Alanine plays a crucial role in the synthesis of peptide-based therapeutics. The incorporation of β-alanine residues can modulate the peptide's physicochemical properties, such as solubility, membrane permeability, and enzymatic stability. Peptides containing β-alanine have shown potential in various therapeutic areas, including antimicrobial peptides, antiviral agents, and drug delivery systems.

Peptidomimetics: BOC-β-Alanine is widely used in the synthesis of peptidomimetics, which are peptide-like compounds designed to mimic the structural and functional properties of natural peptides. Peptidomimetics offer advantages such as improved stability, bioavailability, and target selectivity. BOC-β-Alanine enables the incorporation of β-alanine residues into peptidomimetic scaffolds, enhancing their therapeutic potential.

Neurobiology Research: BOC-β-Alanine is essential in neurobiology research, allowing the synthesis of peptides involved in the study of neuropeptides, neurotransmitters, and ion channels. The incorporation of β-alanine in these peptides can influence their folding, receptor-binding affinity, and biological activity. Such peptides serve as valuable tools for investigating neuronal signaling pathways and developing treatments for neurological disorders.

Market Outlook: The demand for BOC-β-Alanine is steadily growing due to its significance in peptide synthesis and its diverse applications in therapeutic development, peptidomimetics, and neurobiology research. Pharmaceutical companies, academic institutions, and research laboratories rely on BOC-β-Alanine for the synthesis of peptides with enhanced properties and unique functional characteristics. As the field of peptide-based therapeutics and drug discovery expands, the market for amino acid protecting agents like BOC-β-Alanine is expected to experience substantial growth.

Conclusion: BOC-β-Alanine is a versatile and reliable amino acid protecting agent used in peptide synthesis. Its high purity, effective protection of the amino group, and compatibility with various synthesis techniques enable the incorporation of β-alanine residues into peptides, leading to enhanced properties and diverse applications. The applications of BOC-β-Alanine in peptide-based therapeutics, peptidomimetics, and neurobiology research underscore its importance as an essential tool for researchers in the field.

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