BOC-L-Tryptophan
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names BOC-L-Tryptophan
Structure
CAS No. 13139-14-5 Boiling Point (℃) 535.7±45.0 °C at 760 mmHg
Molecular Weight 304.341 Melting Point (℃) 136 °C (dec.)(lit.)
Density 1.3±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C16H20N2O4 Flash Point (℃) 277.8±28.7 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description DL-Lysine (Lysine) is an α-amino acid that is used in the biosynthesis of proteins.
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Nguyen TV, et al. PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange. Pharm Res. 2007 Feb;24(2):353-60.
Synonyms
N-(tert-Butoxycarbonyl)-L-tryptophan
EINECS 236-072-7
Boc-L-Trp
(S)-2-((tert-Butoxycarbonyl)amino)-3-(1H-indol-3-yl)propanoic acid
MFCD00065595
Boc-D-Trp-OH
N-tert-Butoxycarbonyl-L-tryptophan
N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-tryptophan
Na-(tert-Butoxycarbonyl)-L-tryptophan
L-Tryptophan, N-[(1,1-dimethylethoxy)carbonyl]-
(2S)-3-(1H-indol-3-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
Nalpha-Boc-L-Tryptophane
N-Boc-L-tryptophan
Boc-Trp-OH
Boc-L-tryptophan
Product Description
Introduction: BOC-L-Tryptophan is a highly reliable amino acid protecting agent widely used in peptide synthesis. Derived from tryptophan, BOC-L-Tryptophan plays a vital role in protecting amino groups during the assembly of peptide chains. Renowned for its exceptional purity and reliability, BOC-L-Tryptophan has become the preferred choice among chemists and researchers involved in peptide synthesis.

Product Features: Unmatched Purity: BOC-L-Tryptophan is meticulously synthesized to ensure the highest level of purity, surpassing industry standards. Its exceptional purity guarantees minimal impurities, ensuring superior quality results and the synthesis of high-quality peptides.

Effective Amine Protection: BOC-L-Tryptophan acts as an efficient shield for amino groups, preventing undesired side reactions during peptide synthesis. By selectively protecting the amino group, it enables controlled and precise incorporation of amino acids into the growing peptide chain.

Stability: BOC-L-Tryptophan exhibits remarkable stability under typical peptide synthesis conditions, allowing for extended reaction times without degradation. This stability contributes to improved yields and minimizes the risk of undesired side reactions, ensuring efficient peptide assembly.

Applications: Peptide Synthesis: BOC-L-Tryptophan is an indispensable component in solid-phase peptide synthesis (SPPS), the most widely used method for efficient peptide assembly. As an amino acid protecting agent, it ensures the stepwise addition of amino acids, preserving the integrity and controlled growth of the peptide chain.

Pharmaceutical Research: BOC-L-Tryptophan plays a crucial role in the development of peptide-based therapeutics and drug discovery. Its usage facilitates the creation of diverse peptide libraries, allowing researchers to explore structure-activity relationships and identify potential drug candidates.

Neurobiology Studies: BOC-L-Tryptophan finds extensive application in neurobiology studies, particularly in the synthesis of peptides involved in neurotransmission and neuromodulation. Its ability to protect the amino group enables the controlled modification and functionalization of peptides, facilitating investigations into neural pathways and neurochemical interactions.

Market Outlook: The demand for BOC-L-Tryptophan is experiencing consistent growth within the peptide synthesis market due to its reliable performance and compatibility with various synthesis methods. Pharmaceutical companies, academic research institutions, and contract manufacturing organizations (CMOs) heavily rely on BOC-L-Tryptophan for their peptide synthesis projects. With the increasing focus on peptide-based therapeutics and neurobiology research, there is a growing market for high-quality amino acid protecting agents.

Conclusion: BOC-L-Tryptophan stands as a leading amino acid protecting agent in peptide synthesis. Its unmatched purity, effective amine protection, and stability make it an essential tool for chemists and researchers involved in peptide-based studies. With its wide range of applications in peptide synthesis, pharmaceutical research, and neurobiology studies, BOC-L-Tryptophan continues to drive advancements in therapeutic development and our understanding of the complex mechanisms underlying neurobiology.

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