BOC-L-Threonine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Boc-L-Threonine
Structure
CAS No. 2592-18-9 Boiling Point (℃) 387.1±37.0 °C at 760 mmHg
Molecular Weight 219.235 Melting Point (℃) 80-82 °C(lit.)
Density 1.2±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C9H17NO5 Flash Point (℃) 187.9±26.5 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description Boc-Thr-OH is a threonine derivative[1].
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References [1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
Synonyms
N-Boc-L-threonine
BOC-THREONINE
EINECS 219-987-6
BOC-L-THR-OH
N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-threonine
N-Boc-L-Thr-OH
Boc-L-Threionine
N-(tert-Butoxycarbonyl)-L-threonine,Boc-L-threonine
N-(tert-Butoxycarbonyl)-L-threonine
N-Boc-L-Thr
L-Threonine, N-[(1,1-dimethylethoxy)carbonyl]-
BOC-THR-OH
N-Boc-L-IsoSer
N-Boc-Threonine
MFCD00065946
BOC-L-THREONINE-OH
Product Description
Introduction: BOC-L-Threonine is a premium-grade amino acid protecting agent widely employed in peptide synthesis. As a derivative of threonine, BOC-L-Threonine serves as a critical component in safeguarding amino groups during the assembly of peptide chains. Renowned for its exceptional purity and reliability, BOC-L-Threonine has gained significant popularity among chemists and researchers involved in peptide synthesis.

Product Features: Superior Purity: BOC-L-Threonine is meticulously synthesized to ensure an outstanding level of purity, surpassing industry standards. Its exceptional purity guarantees minimal impurities, which may interfere with peptide synthesis, ensuring optimal results and high-quality peptides.

Effective Amine Protection: BOC-L-Threonine acts as an efficient shield for amino groups, preventing undesired side reactions during peptide synthesis. By selectively protecting the amino group, it enables precise and controlled incorporation of amino acids into the growing peptide chain.

Stability: BOC-L-Threonine exhibits remarkable stability under typical peptide synthesis conditions, allowing for extended reaction times without degradation. This stability contributes to improved yields and minimizes the risk of unwanted side reactions, ensuring efficient peptide assembly.

Applications: Peptide Synthesis: BOC-L-Threonine is a crucial tool in solid-phase peptide synthesis (SPPS) methodologies, widely employed for the efficient assembly of peptides. Its role as an amino acid protecting agent enables the stepwise addition of amino acids, ensuring the integrity and controlled growth of the peptide chain.

Pharmaceutical Research: BOC-L-Threonine plays a vital role in the development of peptide-based therapeutics and drug discovery. Its utilization facilitates the creation of diverse peptide libraries, enabling researchers to explore structure-activity relationships and identify potential drug candidates.

Biochemical Studies: BOC-L-Threonine finds extensive application in various biochemical studies, including protein engineering, enzymatic assays, and peptide-protein interactions. Its ability to protect the amino group allows for controlled modifications and functionalization of peptides, facilitating investigations into biological processes and molecular recognition.

Market Outlook: The demand for BOC-L-Threonine is witnessing a steady rise within the peptide synthesis market due to its reliable performance and compatibility with various synthesis methods. Pharmaceutical companies, academic research institutions, and contract manufacturing organizations (CMOs) rely heavily on BOC-L-Threonine for their peptide synthesis projects. With the global market for peptide-based therapeutics expanding, there is a growing need for high-quality amino acid protecting agents.

Conclusion: BOC-L-Threonine stands as a leading amino acid protecting agent in peptide synthesis. Its superior purity, effective amine protection, and stability make it an indispensable component for chemists and researchers involved in peptide-based studies. With its wide range of applications in peptide synthesis, pharmaceutical research, and biochemical studies, BOC-L-Threonine continues to play a crucial role in advancing therapeutic development and molecular investigations.

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