BOC-L-Serine Methyl Ester
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Boc-Ser-OMe
Structure
CAS No. 2766-43-0 Boiling Point (℃) 354.3±32.0 °C at 760 mmHg
Molecular Weight 219.235 Melting Point (℃) 42 °C
Density 1.1±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C9H17NO5 Flash Point (℃) 168.1±25.1 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description Boc-Ser-OMe is a serine derivative[1].
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References [1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
Synonyms
Methyl N-(tert-butoxycarbonyl)-L-serinate
L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester
N-(tert-Butoxycarbonyl)-L-serine methyl ester
Boc-Ser-OMe; Boc-L-serine methyl ester
N-(Boc)-L-serine methylester
N-Boc-L-serine Methyl Ester
BOC-L-Serine methyl ester
N-(tert-Butoxycarbonyl)-L-serine methyl ester,Boc-L-serine methyl ester
(S)-Boc-serine methyl ester
Methyl N-{[(2-methyl-2-propanyl)oxy]carbonyl}-L-serinate
N-t-butoxycarbonyl-D,L-serine methyl ester
MFCD00191869
N-(t-butoxycarbonyl)-L-serine methyl ester
Boc-Ser-OMe
N-Boc-(S)-serine methyl ester
(N-tertbutoxycarbonyl)serine methyl ester
methyl N-t-butoxycarbonyl-D,L-serinate
N-(Boc)-L-serine methyl ester
Product Description
Introduction: BOC-L-Serine methyl ester is a key amino acid protecting agent widely used in peptide synthesis. Its role in protecting amino groups during peptide chain assembly makes it an essential tool for chemists and researchers in the field. BOC-L-Serine methyl ester offers versatility and reliability, making it highly sought after for peptide synthesis applications.

Product Features: High Purity: BOC-L-Serine methyl ester is meticulously synthesized to ensure exceptional purity. It exceeds industry standards, guaranteeing minimal impurities and enabling the synthesis of high-quality peptides.

Effective Amine Protection: BOC-L-Serine methyl ester acts as an efficient protective group for amino groups, preventing undesired side reactions during peptide synthesis. It selectively protects the amino group, allowing precise incorporation of serine residues into the growing peptide chain.

Compatibility with Various Synthesis Methods: BOC-L-Serine methyl ester demonstrates excellent compatibility with a wide range of peptide synthesis methods, including both solution-phase and solid-phase synthesis. Its versatility enables chemists to employ diverse strategies for efficient peptide assembly.

Applications: Peptide Synthesis: BOC-L-Serine methyl ester is indispensable for solid-phase peptide synthesis (SPPS), the primary method for peptide assembly. It facilitates the controlled addition of serine residues, ensuring the proper growth and preservation of the peptide chain's integrity.

Drug Development: BOC-L-Serine methyl ester finds extensive application in the pharmaceutical industry for the synthesis of peptide-based drugs and drug candidates. It allows for the incorporation of serine residues into peptides, enabling the development of therapeutics targeting specific biological pathways or receptors.

Post-Modification Reactions: BOC-L-Serine methyl ester is utilized in post-modification reactions to introduce diverse functional groups or chemical moieties onto serine residues within peptides. These modifications can enhance peptide stability, bioactivity, or enable conjugation with other molecules, expanding their utility in drug discovery and chemical biology research.

Market Outlook: The demand for BOC-L-Serine methyl ester is steadily increasing within the peptide synthesis market due to its reliable performance and compatibility with various synthesis methods. Pharmaceutical companies, academic research institutions, and contract manufacturing organizations (CMOs) rely on BOC-L-Serine methyl ester for their peptide synthesis projects. With the growing interest in peptide-based therapeutics and chemical modifications, there is a rising market for high-quality amino acid protecting agents.

Conclusion: BOC-L-Serine methyl ester is a versatile amino acid protecting agent crucial for peptide synthesis. Its high purity, effective amine protection, and compatibility with diverse synthesis methods make it an indispensable tool for chemists and researchers. The applications of BOC-L-Serine methyl ester in peptide synthesis, drug development, and post-modification reactions contribute to advancements in drug discovery, chemical biology, and the development of innovative therapeutic strategies.

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