BOC-L-Proline
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Boc-L-Proline
Structure
CAS No. 15761-39-4 Boiling Point (℃) 337.2±35.0 °C at 760 mmHg
Molecular Weight 215.246 Melting Point (℃) 133-136ºC
Density 1.2±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C10H17NO4 Flash Point (℃) 157.7±25.9 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description DL-Lysine (Lysine) is an α-amino acid that is used in the biosynthesis of proteins.
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Nguyen TV, et al. PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange. Pharm Res. 2007 Feb;24(2):353-60.
Synonyms
1-(tert-butoxycarbonyl)-L-proline
Boc-L-Pro-OH
tert-Butyloxycarbonyl-L-proline
1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-
N-(tert-Butyloxycarbonyl)-L-proline
MFCD00037324
1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-proline
Boc-L-Proline
1,2-Pyrrolidinedicarboxylic acid, 1- (1,1-dimethylethyl) ester, (S)-
EINECS 239-848-3
N-(tert-Butoxycarbonyl)-L-proline
(S)-1-(tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid
(2S)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-pyrrolidinecarboxylic acid
N-Boc-L-proline
1-tert-Butyloxycarbonyl-L-proline
Boc-Pro-OH
Product Description
Introduction: BOC-L-Proline is a crucial amino acid protecting agent widely employed in peptide synthesis. Its role in safeguarding amino groups during peptide chain assembly makes it an indispensable tool for researchers and chemists in the field. BOC-L-Proline offers exceptional versatility and reliability, making it highly sought after for various peptide synthesis applications.

Product Features: High Purity: BOC-L-Proline is meticulously synthesized to ensure exceptional purity. It surpasses industry standards, guaranteeing minimal impurities and enabling the synthesis of high-quality peptides.

Effective Amine Protection: BOC-L-Proline serves as an efficient protective group for amino groups, preventing undesired side reactions during peptide synthesis. It selectively shields the amino group of proline, facilitating precise incorporation of proline residues into the growing peptide chain.

Compatibility with Diverse Synthesis Methods: BOC-L-Proline demonstrates excellent compatibility with a wide range of peptide synthesis methods, including both solution-phase and solid-phase synthesis. Its versatility allows chemists to employ various strategies for efficient peptide assembly.

Applications: Peptide Synthesis: BOC-L-Proline plays a vital role in solid-phase peptide synthesis (SPPS), the primary method for peptide assembly. It facilitates the controlled addition of proline residues, ensuring the proper growth and preservation of the peptide chain's integrity.

Conformational Studies: BOC-L-Proline is often used in the synthesis of peptides for conformational studies, such as investigating secondary structures like helices and turns. The unique structural characteristics of proline make it a valuable tool for understanding peptide folding and molecular interactions.

Drug Development: BOC-L-Proline finds extensive application in the pharmaceutical industry for the synthesis of peptide-based drugs and drug candidates. It allows for the incorporation of proline residues into peptides, enabling the development of therapeutics targeting specific biological pathways or receptors.

Market Outlook: The demand for BOC-L-Proline is steadily growing within the peptide synthesis market due to its reliable performance and compatibility with various synthesis methods. Pharmaceutical companies, academic research institutions, and contract manufacturing organizations (CMOs) rely on BOC-L-Proline for their peptide synthesis projects. With the increasing interest in peptide-based therapeutics and conformational studies, there is a rising market for high-quality amino acid protecting agents.

Conclusion: BOC-L-Proline is a versatile amino acid protecting agent essential for peptide synthesis. Its high purity, effective amine protection, and compatibility with diverse synthesis methods make it a valuable tool for chemists and researchers. The applications of BOC-L-Proline in peptide synthesis, conformational studies, and drug development contribute to advancements in drug discovery, structural biology, and the development of innovative therapeutic approaches.

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