BOC-L-Phenylalaninol
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names N-Boc-L-phenylalaninol
Structure
CAS No. 66605-57-0 Boiling Point (℃) 410.1±38.0 °C at 760 mmHg
Molecular Weight 251.321 Melting Point (℃) 94-96 °C(lit.)
Density 1.1±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C14H21NO3 Flash Point (℃) 201.8±26.8 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description (S)-tert-butyl 1-hydroxy-3-phenylpropan-2-ylcarbamate is a phenylalanine derivative[1].
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References [1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-886.
Synonyms
Carbamic acid, [1-(hydroxymethyl)-2-phenylethyl]-, 1,1-dimethylethyl ester, (s)-
tert-Butyl [(2S)-1-hydroxy-3-phenylpropan-2-yl]carbamate
tert-butyl N-[(2S)-1-hydroxy-3-phenylpropan-2-yl]carbamate
Carbamic acid, N-[(1S)-2-hydroxy-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester
MFCD00076976
(S)-2-(Boc-amino)-3-phenyl-1-propanol
2-Methyl-2-propanyl [(2S)-1-hydroxy-3-phenyl-2-propanyl]carbamate
Boc-Phe-ol
Boc-Phenylalaninol
Product Description
Introduction: BOC-L-Phenylalaninol is a vital amino acid protecting agent widely used in peptide synthesis. It plays a crucial role in protecting amino groups during the assembly of peptide chains, making it an indispensable tool for chemists and researchers in the field. With its versatility and reliability, BOC-L-Phenylalaninol is highly sought after for peptide synthesis applications.

Product Features: High Purity: BOC-L-Phenylalaninol is synthesized with a strong emphasis on purity to ensure exceptional quality. It surpasses industry standards, guaranteeing minimal impurities and enabling the synthesis of high-quality peptides.

Effective Amine Protection: BOC-L-Phenylalaninol serves as an efficient protective group for amino groups, preventing unwanted side reactions during peptide synthesis. It selectively protects the amino group, allowing for controlled and precise incorporation of amino acids into the growing peptide chain.

Compatibility with Various Synthesis Methods: BOC-L-Phenylalaninol exhibits excellent compatibility with a wide range of peptide synthesis methods, including both solution-phase and solid-phase synthesis. Its versatility enables chemists to employ diverse strategies for efficient peptide assembly.

Applications: Peptide Synthesis: BOC-L-Phenylalaninol is essential for solid-phase peptide synthesis (SPPS), the primary method for peptide assembly. It enables the stepwise addition of phenylalanine residues, ensuring the proper growth and preservation of the peptide chain's integrity.

Drug Development: BOC-L-Phenylalaninol finds extensive application in the pharmaceutical industry for the synthesis of peptide-based drugs and drug candidates. It allows for the incorporation of phenylalanine residues into peptides, facilitating the development of therapeutics targeting specific biological pathways or receptors.

Peptide Modifications: BOC-L-Phenylalaninol is employed in peptide modification strategies, such as introducing functional groups or attaching tags to peptides. These modifications can enhance peptide stability, solubility, or target specificity, expanding their applications in drug discovery, molecular biology, and bioconjugation studies.

Market Outlook: The demand for BOC-L-Phenylalaninol is steadily growing within the peptide synthesis market due to its reliable performance and compatibility with various synthesis methods. Pharmaceutical companies, academic research institutions, and contract manufacturing organizations (CMOs) rely on BOC-L-Phenylalaninol for their peptide synthesis projects. With the increasing interest in peptide-based drugs, medicinal chemistry, and peptide modifications, there is a growing market for high-quality amino acid protecting agents.

Conclusion: BOC-L-Phenylalaninol is a versatile amino acid protecting agent that plays a crucial role in peptide synthesis. Its high purity, effective amine protection, and compatibility with diverse synthesis methods make it an indispensable tool for chemists and researchers. The applications of BOC-L-Phenylalaninol in peptide synthesis, drug development, and peptide modifications contribute to advancements in drug discovery, molecular biology, and the development of innovative therapeutic strategies.

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