BOC-L-Phenylalanine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Boc-L-phenylalanine
Structure
CAS No. 13734-34-4 Boiling Point (℃) 426.6±38.0 °C at 760 mmHg
Molecular Weight 265.305 Melting Point (℃) 85-87 °C(lit.)
Density 1.2±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C14H19NO4 Flash Point (℃) 211.8±26.8 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description DL-Lysine (Lysine) is an α-amino acid that is used in the biosynthesis of proteins.
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Nguyen TV, et al. PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange. Pharm Res. 2007 Feb;24(2):353-60.
Synonyms
N-tert-Butyloxycarbonyl-L-phenylalanine
Boc-phenylalanine
EINECS 237-305-5
N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-phenylalanine
Boc-L-Phenylalanine
(2S)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoic acid
(2S)-2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)-3-phenylpropanoic acid
N-(tert-Butoxycarbonyl)-L-phenylalanin
(S)-2-((tert-Butoxycarbonyl)amino)-3-phenylpropanoic acid
N-(tert-Butoxycarbonyl)-L-phenylalanine
boc-L-Phe
L-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-
N-t-Butyloxycarbonyl-L-phenylalanine
L-Phenylalanine, N-((1,1-dimethylethoxy)carbonyl)-
N-α-t-BOC-L-phenylalanine
N-Boc-L-phenylalanine
MFCD00002663
Boc-Phe-OH
Product Description
Introduction: BOC-L-Phenylalanine is a key amino acid protecting agent widely utilized in peptide synthesis. Derived from phenylalanine, BOC-L-Phenylalanine plays a vital role in protecting amino groups during the assembly of peptide chains. Renowned for its exceptional quality and reliability, BOC-L-Phenylalanine is a preferred choice among chemists and researchers involved in peptide synthesis.

Product Features: High Purity: BOC-L-Phenylalanine is synthesized with meticulous care to ensure the highest level of purity, surpassing industry standards. Its exceptional purity guarantees minimal impurities, resulting in superior quality outcomes and the synthesis of high-quality peptides.

Effective Amine Protection: BOC-L-Phenylalanine acts as a highly efficient shield for amino groups, preventing undesired side reactions during peptide synthesis. By selectively protecting the amino group, it enables controlled and precise incorporation of amino acids into the growing peptide chain.

Enhanced Stability: BOC-L-Phenylalanine offers enhanced stability during various reaction conditions, ensuring reliable protection of the amino group. Its stability preserves the integrity of the peptide chain during synthesis, minimizing undesired side reactions and optimizing peptide yield.

Applications: Peptide Synthesis: BOC-L-Phenylalanine is an indispensable component in solid-phase peptide synthesis (SPPS), the most widely employed method for efficient peptide assembly. Its role as an amino acid protecting agent facilitates the stepwise addition of amino acids, preserving the integrity and controlled growth of the peptide chain.

Drug Development: BOC-L-Phenylalanine finds extensive application in the pharmaceutical industry for the synthesis of peptide-based drugs and drug candidates. It enables the incorporation of phenylalanine residues into peptides, allowing the development of therapeutics targeting specific biological pathways or receptors.

Peptide Modifications: BOC-L-Phenylalanine is employed in peptide modification strategies, including the introduction of functional groups or attachment of tags to peptides. These modifications can enhance peptide stability, solubility, or target specificity, expanding the range of applications in chemical biology and bioconjugation studies.

Market Outlook: The demand for BOC-L-Phenylalanine is experiencing steady growth within the peptide synthesis market owing to its reliable performance and compatibility with various synthesis methods. Pharmaceutical companies, academic research institutions, and contract manufacturing organizations (CMOs) heavily rely on BOC-L-Phenylalanine for their peptide synthesis projects. With the increasing interest in peptide-based drugs, medicinal chemistry, and peptide modifications, there is a growing market for high-quality amino acid protecting agents.

Conclusion: BOC-L-Phenylalanine serves as an essential amino acid protecting agent in peptide synthesis. Its high purity, effective amine protection, and enhanced stability make it a crucial tool for chemists and researchers involved in peptide-based studies. With its wide range of applications in peptide synthesis, drug development, and peptide modifications, BOC-L-Phenylalanine continues to drive advancements in drug discovery, molecular biology, and the development of innovative therapeutic strategies.

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