BOC-L-Glutamic Acid
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names BOC-L-glutamic acid
Structure
CAS No. 2419-94-5 Boiling Point (℃) 435.9±35.0 °C at 760 mmHg
Molecular Weight 247.245 Melting Point (℃) ~110 °C (dec.)
Density 1.3±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C10H17NO6 Flash Point (℃) 217.4±25.9 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description N-Boc-L-glutamic acid is a glutamic acid derivative[1].
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References [1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
Synonyms
Boc-Glu-COOH
L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-
N-(tert-Butoxycarbonyl)-L-glutamic Acid
MFCD00037297
Boc-L-Glutamicacid
N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-glutamic acid
Boc-L-Glu-OH
N-Boc-L-glutamic Acid
(2S)-2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)pentanedioic acid
Boc-D-Glu-OH
Boc-L-Glutamic acid
N-BOC-L-Glu
Boc-Glu-OH
Product Description
BOC-L-Glutamic Acid is a highly reliable amino acid protecting agent widely used in peptide synthesis. Derived from glutamic acid, BOC-L-Glutamic Acid plays a vital role in protecting amino groups during the assembly of peptide chains. Known for its exceptional purity and reliability, BOC-L-Glutamic Acid has become the preferred choice among chemists and researchers engaged in peptide synthesis.

Product Features: Uncompromised Purity: BOC-L-Glutamic Acid is meticulously synthesized to ensure the highest level of purity, surpassing industry standards. Its exceptional purity guarantees minimal impurities, thereby ensuring superior quality results and synthesis of high-quality peptides.

Effective Amine Protection: BOC-L-Glutamic Acid serves as an efficient shield for amino groups, preventing unwanted side reactions during peptide synthesis. By selectively protecting the amino group, it enables controlled and precise incorporation of amino acids into the growing peptide chain.

Stability: BOC-L-Glutamic Acid exhibits remarkable stability under typical peptide synthesis conditions, allowing for extended reaction times without degradation. This stability contributes to improved yields and minimizes the risk of undesired side reactions, ensuring efficient peptide assembly.

Applications: Peptide Synthesis: BOC-L-Glutamic Acid is an indispensable component in solid-phase peptide synthesis (SPPS), the most widely used method for efficient peptide assembly. As an amino acid protecting agent, it ensures the stepwise addition of amino acids, preserving the integrity and controlled growth of the peptide chain.

Pharmaceutical Research: BOC-L-Glutamic Acid plays a crucial role in the development of peptide-based therapeutics and drug discovery. Its usage enables the creation of diverse peptide libraries, allowing researchers to explore structure-activity relationships and identify potential drug candidates.

Biochemical Studies: BOC-L-Glutamic Acid finds extensive application in various biochemical studies, including protein engineering, enzymatic assays, and peptide-protein interactions. Its ability to protect the amino group allows for controlled modifications and functionalization of peptides, facilitating investigations into biological processes and molecular recognition.

Market Outlook: The demand for BOC-L-Glutamic Acid is experiencing consistent growth within the peptide synthesis market due to its reliable performance and compatibility with various synthesis methods. Pharmaceutical companies, academic research institutions, and contract manufacturing organizations (CMOs) rely heavily on BOC-L-Glutamic Acid for their peptide synthesis projects. With the increasing interest in peptide-based therapeutics globally, there is a growing market for high-quality amino acid protecting agents.

Conclusion: BOC-L-Glutamic Acid stands as a leading amino acid protecting agent in peptide synthesis. Its uncompromised purity, effective amine protection, and stability make it an essential tool for chemists and researchers involved in peptide-based studies. With its wide range of applications in peptide synthesis, pharmaceutical research, and biochemical studies, BOC-L-Glutamic Acid continues to drive advancements in therapeutic development and molecular investigations.

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