BOC-L-Alaninol
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names N-Boc-L-alaninol
Structure
CAS No. 79069-13-9 Boiling Point (℃) 276.4±23.0 °C at 760 mmHg
Molecular Weight 175.225 Melting Point (℃) 59-62 °C(lit.)
Density 1.0±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C8H17NO3 Flash Point (℃) 121.0±22.6 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description DL-Lysine (Lysine) is an α-amino acid that is used in the biosynthesis of proteins.
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Nguyen TV, et al. PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange. Pharm Res. 2007 Feb;24(2):353-60.
Synonyms
Carbamic acid, (2-hydroxy-1-methylethyl)-, 1,1-dimethylethyl ester, (s)-
Carbamic acid, N-[(1S)-2-hydroxy-1-methylethyl]-, 1,1-dimethylethyl ester
tert-Butyl [(2S)-1-hydroxypropan-2-yl]carbamate
tert-butyl N-[(2S)-1-hydroxypropan-2-yl]carbamate
MFCD00043121
N-Boc-S-alaninol
2-Methyl-2-propanyl [(2S)-1-hydroxy-2-propanyl]carbamate
Boc-Ala-ol
Boc-L-alaninol
Product Description
Introduction: BOC-L-Alaninol is a vital amino acid protecting agent widely used in peptide synthesis. As an essential component of the peptide chemist's toolkit, BOC-L-Alaninol plays a crucial role in protecting amino groups during the assembly of peptide chains. Known for its versatility and reliability, BOC-L-Alaninol has become a preferred choice among chemists and researchers involved in peptide synthesis.

Product Features: High Purity: BOC-L-Alaninol is carefully synthesized to ensure exceptional purity, surpassing industry standards. Its high purity guarantees minimal impurities, enabling the synthesis of high-quality peptides and reliable results.

Effective Amine Protection: BOC-L-Alaninol serves as an efficient protective group for amino groups, preventing undesired side reactions during peptide synthesis. By selectively protecting the amino group, it facilitates the controlled and precise incorporation of amino acids into the growing peptide chain.

Compatibility with Various Synthesis Methods: BOC-L-Alaninol exhibits excellent compatibility with a wide range of peptide synthesis methods, including both solution-phase and solid-phase synthesis. Its versatility allows chemists to employ diverse strategies for efficient peptide assembly.

Applications: Peptide Synthesis: BOC-L-Alaninol plays a fundamental role in solid-phase peptide synthesis (SPPS), the primary method for efficient peptide assembly. As an amino acid protecting agent, it enables the stepwise addition of amino acids, ensuring the proper growth and preservation of the peptide chain's integrity.

Drug Development: BOC-L-Alaninol finds extensive application in the pharmaceutical industry for the synthesis of peptide-based drugs and drug candidates. It allows for the incorporation of alanine residues into peptides, facilitating the development of therapeutics targeting specific biological pathways or receptors.

Peptide Modifications: BOC-L-Alaninol is employed in peptide modification strategies, such as introducing functional groups or attaching tags to peptides. These modifications can enhance peptide stability, solubility, or target specificity, expanding their applications in drug discovery, molecular biology, and bioconjugation studies.

Market Outlook: The demand for BOC-L-Alaninol is steadily growing within the peptide synthesis market due to its reliable performance and compatibility with various synthesis methods. Pharmaceutical companies, academic research institutions, and contract manufacturing organizations (CMOs) rely on BOC-L-Alaninol for their peptide synthesis projects. With the increasing interest in peptide-based drugs, medicinal chemistry, and peptide modifications, there is a growing market for high-quality amino acid protecting agents.

Conclusion: BOC-L-Alaninol stands as a versatile amino acid protecting agent in peptide synthesis. Its high purity, effective amine protection, and compatibility with diverse synthesis methods make it an indispensable tool for chemists and researchers involved in peptide-based studies. With its wide range of applications in peptide synthesis, drug development, and peptide modifications, BOC-L-Alaninol continues to drive advancements in drug discovery, molecular biology, and the development of innovative therapeutic strategies.

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