BOC-DL-Phenylglycine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Boc-DL-Phg-OH
Structure
CAS No. 3601-66-9 Boiling Point (℃) 407.2±38.0 °C at 760 mmHg
Molecular Weight 251.278 Melting Point (℃) 111-112℃
Density 1.2±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C13H17NO4 Flash Point (℃) 200.1±26.8 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description Boc-DL-Phg-OH is a Glycine (HY-Y0966) derivative[1].
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References [1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
Synonyms
Benzeneacetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-
[(tert-Butoxycarbonyl)amino](phenyl)acetic acid
MFCD00971063
({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)(phenyl)acetic acid
N-Boc-DL-phenylglycine
TERT-BUTOXYCARBONYLAMINO-PHENYL-ACETIC ACID
BOC-DL-(PHENYL)GLY-OH
Product Description
BOC-DL-Phenylglycine is a versatile amino acid protecting agent widely used in peptide synthesis. Derived from phenylglycine, BOC-DL-Phenylglycine plays a crucial role in protecting amino groups during the assembly of peptide chains. Known for its exceptional quality and reliability, BOC-DL-Phenylglycine has become a preferred choice among chemists and researchers involved in peptide synthesis.

Product Features: Superior Purity: BOC-DL-Phenylglycine is meticulously synthesized to ensure the highest level of purity, surpassing industry standards. Its exceptional purity guarantees minimal impurities, ensuring superior quality results and the synthesis of high-quality peptides.

Effective Amine Protection: BOC-DL-Phenylglycine acts as an efficient shield for amino groups, preventing undesired side reactions during peptide synthesis. By selectively protecting the amino group, it enables controlled and precise incorporation of amino acids into the growing peptide chain.

Enhanced Solubility: BOC-DL-Phenylglycine exhibits improved solubility properties, allowing for easy dissolution in common solvents used in peptide synthesis. This characteristic enhances its compatibility with various reaction conditions and facilitates efficient peptide assembly.

Applications: Peptide Synthesis: BOC-DL-Phenylglycine is an essential component in solid-phase peptide synthesis (SPPS), the most widely used method for efficient peptide assembly. Its role as an amino acid protecting agent enables the stepwise addition of amino acids, preserving the integrity and controlled growth of the peptide chain.

Medicinal Chemistry: BOC-DL-Phenylglycine finds significant application in medicinal chemistry for the synthesis of peptide-based drugs and drug candidates. Its utilization allows for the creation of diverse peptide libraries, facilitating structure-activity relationship studies and the identification of potential therapeutic leads.

Peptide Mimetics: BOC-DL-Phenylglycine is employed in the design and synthesis of peptide mimetics, which are non-peptide compounds that mimic the structural and functional properties of peptides. These peptide mimetics offer advantages in drug discovery, including improved stability, bioavailability, and target selectivity.

Market Outlook: The demand for BOC-DL-Phenylglycine is experiencing steady growth within the peptide synthesis market due to its reliable performance and compatibility with various synthesis methods. Pharmaceutical companies, academic research institutions, and contract manufacturing organizations (CMOs) heavily rely on BOC-DL-Phenylglycine for their peptide synthesis projects. With the increasing interest in peptide-based drugs, medicinal chemistry, and peptide mimetics, there is a growing market for high-quality amino acid protecting agents.

Conclusion: BOC-DL-Phenylglycine stands as a versatile amino acid protecting agent in peptide synthesis. Its superior purity, effective amine protection, and enhanced solubility make it an indispensable tool for chemists and researchers involved in peptide-based studies. With its wide range of applications in peptide synthesis, medicinal chemistry, and peptide mimetics, BOC-DL-Phenylglycine continues to drive advancements in drug discovery and the development of innovative therapeutic strategies.

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