BOC-D-Serine Methyl Ester
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Boc-D-Serine methyl ester
Structure
CAS No. 95715-85-8 Boiling Point (℃) 354.3±32.0 °C at 760 mmHg
Molecular Weight 219.235 Melting Point (℃) N/A
Density 1.1±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C9H17NO5 Flash Point (℃) 168.1±25.1 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description (R)-Methyl 2-(tert-butoxycarbonylamino)-3-hydroxypropanoate is a serine derivative[1].
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References [1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
Synonyms
Methyl N-(tert-butoxycarbonyl)-D-serinate
methyl (2R)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
Methyl N-{[(2-methyl-2-propanyl)oxy]carbonyl}-D-serinate
MFCD00270516
D-Serine, N-[(1,1-dimethylethoxy)carbonyl]-, methyl ester
Boc-D-Ser-OMe
Product Description
Introduction: BOC-D-Serine Methyl Ester is a versatile amino acid protecting agent widely used in peptide synthesis. Derived from serine, BOC-D-Serine Methyl Ester plays a crucial role in protecting amino groups during the assembly of peptide chains. Known for its exceptional quality and reliability, BOC-D-Serine Methyl Ester has become a preferred choice among chemists and researchers involved in peptide synthesis.

Product Features: High Purity: BOC-D-Serine Methyl Ester is meticulously synthesized to ensure the highest level of purity, surpassing industry standards. Its exceptional purity guarantees minimal impurities, ensuring superior quality results and the synthesis of high-quality peptides.

Effective Amine Protection: BOC-D-Serine Methyl Ester acts as an efficient shield for amino groups, preventing undesired side reactions during peptide synthesis. By selectively protecting the amino group, it enables controlled and precise incorporation of amino acids into the growing peptide chain.

Methyl Ester Functionality: The methyl ester functionality of BOC-D-Serine Methyl Ester offers additional advantages in peptide synthesis. It provides increased stability to the amino acid, allowing for protection during various reaction conditions. Moreover, the methyl ester group can be easily removed to reveal the free amino group when required.

Applications: Peptide Synthesis: BOC-D-Serine Methyl Ester is an essential component in solid-phase peptide synthesis (SPPS), the most widely used method for efficient peptide assembly. Its role as an amino acid protecting agent enables the stepwise addition of amino acids, preserving the integrity and controlled growth of the peptide chain.

Medicinal Chemistry: BOC-D-Serine Methyl Ester finds significant application in medicinal chemistry for the synthesis of peptide-based drugs and drug candidates. Its utilization allows for the creation of diverse peptide libraries, facilitating structure-activity relationship studies and the identification of potential therapeutic leads.

Peptide Modifications: BOC-D-Serine Methyl Ester is employed in peptide modification strategies, such as the introduction of functional groups or attachment of tags to peptides. These modifications can impart desired properties to peptides, such as improved stability, solubility, or target specificity, expanding their applications in drug discovery and bioconjugation studies.

Market Outlook: The demand for BOC-D-Serine Methyl Ester is experiencing steady growth within the peptide synthesis market due to its reliable performance and compatibility with various synthesis methods. Pharmaceutical companies, academic research institutions, and contract manufacturing organizations (CMOs) heavily rely on BOC-D-Serine Methyl Ester for their peptide synthesis projects. With the increasing interest in peptide-based drugs, medicinal chemistry, and peptide modifications, there is a growing market for high-quality amino acid protecting agents.

Conclusion: BOC-D-Serine Methyl Ester stands as a versatile amino acid protecting agent in peptide synthesis. Its high purity, effective amine protection, and methyl ester functionality make it an indispensable tool for chemists and researchers involved in peptide-based studies. With its wide range of applications in peptide synthesis, medicinal chemistry, and peptide modifications, BOC-D-Serine Methyl Ester continues to drive advancements in drug discovery and the development of innovative therapeutic strategies.

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