BOC-D-Proline
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names BOC-D-Proline
Structure
CAS No. 37784-17-1 Boiling Point (℃) 337.2±35.0 °C at 760 mmHg
Molecular Weight 215.246 Melting Point (℃) 134-137 °C(lit.)
Density 1.2±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C10H17NO4 Flash Point (℃) 157.7±25.9 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description DL-Lysine (Lysine) is an α-amino acid that is used in the biosynthesis of proteins.
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Nguyen TV, et al. PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange. Pharm Res. 2007 Feb;24(2):353-60.
Synonyms
1-(tert-butoxycarbonyl)-L-proline
Boc-L-Pro-OH
tert-Butyloxycarbonyl-L-proline
(R)-1-(tert-Butoxycarbonyl)pyrrolidine-2-carboxylic acid
1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-
N-(tert-Butyloxycarbonyl)-L-proline
BOC-D-Proline
N-Boc-D-Proline
1-(tert-butoxycarbonyl)proline
1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-proline
1,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester
Boc-D-Pro-OH
1,2-Pyrrolidinedicarboxylic acid, 1- (1,1-dimethylethyl) ester, (S)-
N-(tert-Butoxycarbonyl)-D-proline
(2R)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid
(2S)-1-{[(2-Methyl-2-propanyl)oxy]carbonyl}-2-pyrrolidinecarboxylic acid
MFCD00063226
1-{[(2-Methyl-2-propanyl)oxy]carbonyl}proline
1-tert-Butyloxycarbonyl-L-proline
Product Description
BOC-D-proline is a derivative of the amino acid proline, which is used as a protecting group in peptide synthesis. As a BOC-protected amino acid, it is commonly used in the solid-phase synthesis of peptides and as a building block for pharmaceuticals and agrochemicals. BOC-D-proline is also used as a chiral auxiliary in asymmetric synthesis and as a starting material for the preparation of various compounds.

Production BOC-D-proline is typically synthesized by reacting BOC-anhydride with D-proline in the presence of a base such as triethylamine. After purification, the resulting product is a white to off-white powder that is stable under normal conditions.

Applications BOC-D-proline is widely used in peptide synthesis as a protecting group for the proline residue. It is commonly used in the solid-phase synthesis of peptides due to its compatibility with standard peptide synthesis protocols. BOC-D-proline can also be used as a chiral auxiliary in asymmetric synthesis to induce stereoselectivity. Additionally, it is used as a starting material for the synthesis of various compounds, including pharmaceuticals, agrochemicals, and specialty chemicals.

Market Analysis The demand for BOC-D-proline is driven by the growing pharmaceutical and agrochemical industries, which require a variety of amino acid derivatives for the production of drugs and crop protection agents. As a result, the market for BOC-D-proline is expected to experience steady growth in the coming years. The increasing focus on peptide-based drugs and the rising demand for green chemistry are also expected to contribute to the growth of the BOC-D-proline market.

Conclusion In conclusion, BOC-D-proline is a key intermediate in peptide synthesis and the production of pharmaceuticals, agrochemicals, and specialty chemicals. Its use as a protecting group and chiral auxiliary make it a valuable building block in the production of a wide range of compounds. The growing demand for BOC-D-proline in the pharmaceutical and agrochemical industries is expected to drive market growth in the coming years.

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