BOC-D-Phenylglycinol
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Boc-D-Phenylglycinol
Structure
CAS No. 102089-74-7 Boiling Point (℃) 389.4±35.0 °C at 760 mmHg
Molecular Weight 237.295 Melting Point (℃) 137-139 °C(lit.)
Density 1.1±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C13H19NO3 Flash Point (℃) 189.3±25.9 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description DL-Lysine (Lysine) is an α-amino acid that is used in the biosynthesis of proteins.
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Nguyen TV, et al. PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange. Pharm Res. 2007 Feb;24(2):353-60.
Synonyms
N-Boc-D-2-phenylglycinol
Carbamic acid, N-(2-hydroxy-2-phenylethyl)-, 1,1-dimethylethyl ester
Boc-D-Phenylglycinol
tert-butyl N-[(1R)-2-hydroxy-1-phenylethyl]carbamate
(R)-2-(tert-Butoxycarbonylamino)-2-phenylethanol
2-Methyl-2-propanyl (2-hydroxy-2-phenylethyl)carbamate
1,1-Dimethylethyl N-[(1R)-2-hydroxy-1-phenylethyl]carbamate
(R)-N-Boc-D-α-phenylglycinol
MFCD00274205
(R)-tert-Butyl (2-hydroxy-1-phenylethyl)carbamate
Carbamic acid, N-[(1R)-2-hydroxy-1-phenylethyl]-, 1,1-dimethylethyl ester
N-t-BOC-D-Phenylglycinol
N-(tert-Butoxycarbonyl)-D-2-phenylglycinol
2-Methyl-2-propanyl [(1R)-2-hydroxy-1-phenylethyl]carbamate
tert-Butyl [(1R)-2-hydroxy-1-phenylethyl]carbamate
tert-Butyl (2-hydroxy-2-phenylethyl)carbamate
Boc-D-Phg-OL
Product Description
Introduction: BOC-D-Phenylglycinol is a versatile amino acid protecting agent widely used in peptide synthesis. Derived from phenylglycinol, BOC-D-Phenylglycinol plays a crucial role in protecting amino groups during the assembly of peptide chains. Known for its exceptional quality and reliability, BOC-D-Phenylglycinol has become a preferred choice among chemists and researchers involved in peptide synthesis.

Product Features: High Purity: BOC-D-Phenylglycinol is meticulously synthesized to ensure the highest level of purity, surpassing industry standards. Its exceptional purity guarantees minimal impurities, ensuring superior quality results and the synthesis of high-quality peptides.

Effective Amine Protection: BOC-D-Phenylglycinol acts as an efficient shield for amino groups, preventing undesired side reactions during peptide synthesis. By selectively protecting the amino group, it enables controlled and precise incorporation of amino acids into the growing peptide chain.

Enhanced Stability: BOC-D-Phenylglycinol offers enhanced stability, allowing for reliable protection of the amino group during various reaction conditions. Its stability ensures the integrity of the peptide chain during synthesis, minimizing undesired side reactions and optimizing peptide yield.

Applications: Peptide Synthesis: BOC-D-Phenylglycinol is an indispensable component in solid-phase peptide synthesis (SPPS), the most widely used method for efficient peptide assembly. Its role as an amino acid protecting agent enables the stepwise addition of amino acids, preserving the integrity and controlled growth of the peptide chain.

Medicinal Chemistry: BOC-D-Phenylglycinol finds significant application in medicinal chemistry for the synthesis of peptide-based drugs and drug candidates. Its utilization allows for the creation of diverse peptide libraries, facilitating structure-activity relationship studies and the identification of potential therapeutic leads.

Peptide Modification: BOC-D-Phenylglycinol is employed in peptide modification strategies, such as the introduction of functional groups or attachment of tags to peptides. These modifications can enhance peptide stability, solubility, or target specificity, enabling a wide range of applications in chemical biology and bioconjugation studies.

Market Outlook: The demand for BOC-D-Phenylglycinol is experiencing steady growth within the peptide synthesis market due to its reliable performance and compatibility with various synthesis methods. Pharmaceutical companies, academic research institutions, and contract manufacturing organizations (CMOs) heavily rely on BOC-D-Phenylglycinol for their peptide synthesis projects. With the increasing interest in peptide-based drugs, medicinal chemistry, and peptide modifications, there is a growing market for high-quality amino acid protecting agents.

Conclusion: BOC-D-Phenylglycinol stands as a versatile amino acid protecting agent in peptide synthesis. Its high purity, effective amine protection, and enhanced stability make it an indispensable tool for chemists and researchers involved in peptide-based studies. With its wide range of applications in peptide synthesis, medicinal chemistry, and peptide modifications, BOC-D-Phenylglycinol continues to drive advancements in drug discovery and the development of innovative therapeutic strategies.

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