BOC-D-Phenylglycine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Boc-D-Phg-OH
Structure
CAS No. 33125-05-2 Boiling Point (℃) 382.6±25.0 °C at 760 mmHg
Molecular Weight 251.278 Melting Point (℃) 88-91 °C
Density 1.2±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C13H17NO4 Flash Point (℃) 185.2±23.2 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description (αR)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]benzeneacetic acid is a Glycine (HY-Y0966) derivative[1].
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References [1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
Synonyms
Boc-L-α-phenylglycine
Boc-L-a-phenylglycine
N-(tert-Butoxycarbonyl)-D-2-phenylglycine
N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-N-phenylglycine
N-Boc-L-2-phenylglycine
N-Boc-(S)-2-phenylglycine
BOC-L-alpha-phenylglycine
Boc-D-Phg-OH
N-tert-butoxycarbonyl-L-phenylglycine
[(tert-Butoxycarbonyl)amino](phenyl)acetic acid
(S)-N-Boc-phenylglycine
N-(tert-Butoxycarbonyl)-N-phenylglycine
MFCD00065588
BOC-DL-(PHENYL)GLY-OH
BOC-D-alpha-phenylglycine
(S)-N-(tert-butoxycarbonyl)-2-phenylglycine
Boc-L-phenylglycine
Product Description
Introduction: BOC-D-Phenylglycine is a crucial amino acid protecting agent widely used in peptide synthesis. With its exceptional compatibility, stability, and versatility, BOC-D-Phenylglycine enables the synthesis of peptides containing phenylglycine residues. Its high purity and reliable performance make it an indispensable tool for chemists and researchers involved in peptide synthesis projects.

Product Features: High Purity: BOC-D-Phenylglycine is produced with meticulous care to ensure the highest level of purity, minimizing impurities. Its superior quality guarantees the synthesis of peptides with excellent purity and structural integrity.

Effective Protecting Group: BOC-D-Phenylglycine serves as a reliable protecting group for the amino group of phenylglycine, preventing unwanted reactions during peptide chain elongation. By selectively shielding the amino group, it enables controlled incorporation of phenylglycine into peptides.

Versatile Applications: BOC-D-Phenylglycine finds extensive use in the synthesis of peptides with phenylglycine residues. Peptides containing phenylglycine exhibit unique conformational properties, increased stability, and altered binding affinity, making them valuable in drug discovery, peptide-based therapeutics, and biochemical research.

Applications: Peptide-Based Therapeutics: BOC-D-Phenylglycine plays a crucial role in the synthesis of peptide-based therapeutics. Incorporation of phenylglycine residues can enhance the peptide's stability, improve protease resistance, and fine-tune the peptide's interactions with its target, increasing therapeutic efficacy. Peptide drugs containing phenylglycine have shown potential in areas such as oncology, diabetes, and neurodegenerative diseases.

Molecular Probes and Imaging Agents: BOC-D-Phenylglycine facilitates the synthesis of peptides used as molecular probes and imaging agents. These peptides can be labeled with various fluorophores or imaging moieties, enabling targeted imaging of specific cells or tissues. Phenylglycine-containing peptides have been employed in molecular imaging techniques, such as fluorescence imaging and positron emission tomography (PET).

Biochemical Research: BOC-D-Phenylglycine is an essential tool in biochemical research, enabling the synthesis of peptides with phenylglycine residues for studying protein-protein interactions, enzymatic mechanisms, and signal transduction pathways. By incorporating phenylglycine, researchers can gain valuable insights into the structure-function relationships of proteins and develop novel tools for investigating biological processes.

Market Outlook: The demand for BOC-D-Phenylglycine is steadily growing due to its significant role in peptide synthesis and biochemical research. Pharmaceutical companies, academic institutions, and research laboratories extensively utilize BOC-D-Phenylglycine in the development of peptide-based therapeutics, molecular probes, and imaging agents. As the field of peptide therapeutics and molecular imaging continues to advance, the market for amino acid protecting agents like BOC-D-Phenylglycine is expected to witness continued growth.

Conclusion: BOC-D-Phenylglycine is a versatile and reliable amino acid protecting agent used in peptide synthesis. Its high purity, effective protection of the amino group, and compatibility with various synthesis techniques enable the incorporation of phenylglycine residues into peptides, leading to enhanced structural diversity and unique functional properties.

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