BOC-D-Phenylalaninol
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names N-Boc-D-phenylalaninol
Structure
CAS No. 106454-69-7 Boiling Point (℃) 410.1±38.0 °C at 760 mmHg
Molecular Weight 251.321 Melting Point (℃) 95-98ºC
Density 1.1±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C14H21NO3 Flash Point (℃) 201.8±26.8 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description DL-Lysine (Lysine) is an α-amino acid that is used in the biosynthesis of proteins.
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro DL-Lysine (Lys) is a high affinity, basic amino acid substrate for amino acid transporter b0,+ with Km value ranging from 100-400 μM[1].
References [1]. Nguyen TV, et al. PEPT1 enhances the uptake of gabapentin via trans-stimulation of b0,+ exchange. Pharm Res. 2007 Feb;24(2):353-60.
Synonyms
tert-butyl N-[(2R)-1-hydroxy-3-phenylpropan-2-yl]carbamate
N-(tert-Butoxycarbonyl)-D-phenylalaninol
Carbamic acid, [1-(hydroxymethyl)-2-phenylethyl]-, 1,1-dimethylethyl ester, (s)-
Carbamic acid, N-[(1S)-2-hydroxy-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester
N-Boc-D-Phenylalaninol
(R)-tert-Butyl (1-hydroxy-3-phenylpropan-2-yl)carbamate
Carbamic acid, N-[(1R)-2-hydroxy-1-(phenylmethyl)ethyl]-, 1,1-dimethylethyl ester
N-t-BOC-D-Phenylalaninol
tert-Butyl [(2R)-1-hydroxy-3-phenylpropan-2-yl]carbamate
tert-Butyl [(2S)-1-hydroxy-3-phenylpropan-2-yl]carbamate
MFCD05865075
(R)-2-(Boc-amino)-3-phenyl-1-propanol
2-Methyl-2-propanyl [(2R)-1-hydroxy-3-phenyl-2-propanyl]carbamate
(S)-2-(Boc-amino)-3-phenyl-1-propanol
2-Methyl-2-propanyl [(2S)-1-hydroxy-3-phenyl-2-propanyl]carbamate
(R)-2-(tert-Butoxycarbonylamino)-3-phenyl-1-propanol
Boc-D-Phe-ol
Boc-D-Phenylalaninol
Product Description
BOC-D-Phenylalaninol is a vital amino acid protecting agent widely used in peptide synthesis. With its exceptional properties and compatibility with peptide assembly techniques, BOC-D-Phenylalaninol enables the synthesis of peptides containing phenylalaninol residues. Its high purity, reliability, and versatility make it an essential tool for chemists and researchers involved in peptide synthesis projects.

Product Features: High Purity: BOC-D-Phenylalaninol is manufactured with meticulous attention to purity, ensuring minimal impurities. Its superior quality guarantees the synthesis of peptides with excellent purity and structural integrity.

Effective Protecting Group: BOC-D-Phenylalaninol serves as a reliable protecting group for the phenolic hydroxyl group, preventing unwanted reactions during peptide chain elongation. It selectively shields the hydroxyl group, allowing controlled incorporation of phenylalaninol into peptides.

Structural Diversity: BOC-D-Phenylalaninol facilitates the synthesis of peptides with unique structural characteristics. The incorporation of phenylalaninol residues in peptides can confer altered conformational properties, enhanced hydrophobic interactions, and improved binding affinity, making it valuable in drug discovery, peptide-based therapeutics, and biochemical research.

Applications: Peptide-Based Therapeutics: BOC-D-Phenylalaninol plays a crucial role in the synthesis of peptide-based therapeutics. The incorporation of phenylalaninol residues can enhance the peptide's stability, improve cell penetration, and optimize target interactions. Peptides containing phenylalaninol have shown potential in various therapeutic areas, including oncology, immunology, and metabolic disorders.

Peptidomimetics: BOC-D-Phenylalaninol is utilized in the synthesis of peptidomimetics, which are peptide-like compounds designed to mimic the structural and functional properties of natural peptides. Peptidomimetics have gained significant attention in drug discovery due to their improved stability, oral bioavailability, and target specificity. BOC-D-Phenylalaninol enables the incorporation of phenylalaninol residues in peptidomimetic scaffolds, enhancing their therapeutic potential.

Biochemical Research: BOC-D-Phenylalaninol is an essential tool in biochemical research, enabling the synthesis of peptides with phenylalaninol residues for studying protein-ligand interactions, enzyme mechanisms, and signal transduction pathways. The presence of phenylalaninol in these peptides imparts unique properties, allowing researchers to gain insights into structure-function relationships and design novel compounds for biological studies.

Market Outlook: The demand for BOC-D-Phenylalaninol is steadily growing due to its significance in peptide synthesis and its diverse applications in therapeutic development, peptidomimetics, and biochemical research. Pharmaceutical companies, academic institutions, and research laboratories rely on BOC-D-Phenylalaninol for the synthesis of peptides with enhanced structural diversity and unique functional properties. As the field of peptide-based therapeutics and drug discovery continues to expand, the market for amino acid protecting agents like BOC-D-Phenylalaninol is expected to experience substantial growth.

Conclusion: BOC-D-Phenylalaninol is a versatile and reliable amino acid protecting agent used in peptide synthesis. Its high purity, effective protection of the phenolic hydroxyl group, and compatibility with various synthesis techniques enable the incorporation of phenylalaninol residues into peptides, leading to enhanced structural diversity and unique functional properties.

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