BOC-D-Glutamic Acid
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Boc-D-Glu-OH
Structure
CAS No. 34404-28-9 Boiling Point (℃) 435.9±35.0 °C at 760 mmHg
Molecular Weight 247.245 Melting Point (℃) 108 °C(dec.)
Density 1.3±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C10H17NO6 Flash Point (℃) 217.4±25.9 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description BOC-D-GLU-OH is a glutamic acid derivative[1].
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References [1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
Synonyms
Boc-Glu-COOH
N-(Tert-Butoxycarbonyl)-D-Glutamic Acid
L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-
N-(tert-Butoxycarbonyl)-L-glutamic Acid
Boc-L-Glutamicacid
N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-L-glutamic acid
Boc-L-Glu-OH
N-Boc-L-glutamic Acid
Boc-D-glutamic acid
(2S)-2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)pentanedioic acid
Boc-D-Glu-OH
N-Boc-D-glutamic Acid
Boc-L-Glutamic acid
N-BOC-L-Glu
N-Boc-D-Glu
MFCD00190790
Boc-Glu-OH
(R)-2-((tert-Butoxycarbonyl)amino)pentanedioic acid
Product Description
BOC-D-Glutamic Acid is a highly versatile amino acid protecting agent widely utilized in peptide synthesis. Derived from glutamic acid, BOC-D-Glutamic Acid plays a crucial role in protecting amino groups during the assembly of peptide chains. Its exceptional quality and reliability have made it a preferred choice among chemists and researchers engaged in peptide synthesis.

Product Features: High Purity: BOC-D-Glutamic Acid is meticulously synthesized to ensure the highest level of purity, surpassing industry standards. Its exceptional purity guarantees minimal impurities, ensuring superior quality results and the synthesis of high-quality peptides.

Effective Amine Protection: BOC-D-Glutamic Acid acts as an efficient protective group for amino groups, preventing undesired side reactions during peptide synthesis. By selectively protecting the amino group, it enables controlled and precise incorporation of amino acids into the growing peptide chain.

Compatibility with Various Synthesis Methods: BOC-D-Glutamic Acid exhibits excellent compatibility with a wide range of peptide synthesis methods, including both solution-phase and solid-phase synthesis. Its versatility allows chemists to employ diverse strategies in peptide assembly.

Applications: Peptide Synthesis: BOC-D-Glutamic Acid plays a vital role in solid-phase peptide synthesis (SPPS), the predominant method for efficient peptide assembly. As an amino acid protecting agent, it enables stepwise addition of amino acids, preserving the integrity and controlled growth of the peptide chain.

Drug Development: BOC-D-Glutamic Acid finds extensive application in the pharmaceutical industry for the synthesis of peptide-based drugs and drug candidates. It enables the incorporation of glutamic acid residues into peptides, facilitating the development of therapeutics targeting specific biological pathways or receptors.

Peptide Modifications: BOC-D-Glutamic Acid is employed in peptide modification strategies, such as introducing functional groups or attaching tags to peptides. These modifications can enhance peptide stability, solubility, or target specificity, expanding their applications in drug discovery, molecular biology, and bioconjugation studies.

Market Outlook: The demand for BOC-D-Glutamic Acid is witnessing steady growth within the peptide synthesis market owing to its reliable performance and compatibility with various synthesis methods. Pharmaceutical companies, academic research institutions, and contract manufacturing organizations (CMOs) rely on BOC-D-Glutamic Acid for their peptide synthesis projects. With the rising interest in peptide-based drugs, medicinal chemistry, and peptide modifications, there is a growing market for high-quality amino acid protecting agents.

Conclusion: BOC-D-Glutamic Acid stands as a versatile amino acid protecting agent in peptide synthesis. Its high purity, effective amine protection, and compatibility with diverse synthesis methods make it an indispensable tool for chemists and researchers involved in peptide-based studies. With its wide range of applications in peptide synthesis, drug development, and peptide modifications, BOC-D-Glutamic Acid continues to drive advancements in drug discovery, molecular biology, and the development of innovative therapeutic strategies.

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