Boc-D-Asparagine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Boc-D-Asparagine
Structure
CAS No. 75647-01-7 Boiling Point (℃) 481.7±40.0 °C at 760 mmHg
Molecular Weight 232.234 Melting Point (℃) 165-169 °C
Density 1.3±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C9H16N2O5 Flash Point (℃) 245.1±27.3 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description (R)-4-Amino-2-((tert-butoxycarbonyl)amino)-4-oxobutanoic acid is an asparagine derivative[1].
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References [1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144.
Synonyms
N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-D-asparagine
Nalpha-Boc-D-asparagine
Boc-D-Asn-OH
MFCD00065558
(2R)-4-Amino-2-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)-4-oxobutanoic acid
N-(tert-Butoxycarbonyl)-D-asparagine
Boc-L-Asn-OH
Boc-D-asparagine
N-(tert-Butoxycarbonyl)-D-asparagin
BOC-D-ASN
EINECS 231-405-2
D-Asparagine, N-[(1,1-dimethylethoxy)carbonyl]-
Product Description
BOC-D-Asparagine is a high-quality amino acid protecting agent widely used in peptide synthesis. As a derivative of asparagine, BOC-D-Asparagine plays a crucial role in protecting the amino groups during the assembly of peptide chains. Its exceptional purity and reliability make it a preferred choice among chemists and researchers involved in peptide synthesis.

Product Features: Excellent Purity: BOC-D-Asparagine is meticulously synthesized to ensure a high level of purity, surpassing industry standards. Its purity guarantees minimal impurities that could interfere with peptide synthesis, thus ensuring high-quality results.

Effective Amine Protection: BOC-D-Asparagine acts as a safeguard for the amino group, preventing unwanted side reactions during peptide synthesis. By selectively protecting the amino group, it allows for controlled and precise incorporation of amino acids into the peptide chain.

Stability: BOC-D-Asparagine exhibits exceptional stability under typical peptide synthesis conditions, enabling extended reaction times without degradation. Its stability contributes to improved yields and reduces the risk of undesired side reactions.

Applications: Peptide Synthesis: BOC-D-Asparagine is an essential tool in the solid-phase peptide synthesis (SPPS) method, commonly employed for the efficient assembly of peptides. It serves as an amino acid protecting agent during the stepwise addition of amino acids, ensuring the integrity of the peptide chain throughout the synthesis process.

Drug Discovery: BOC-D-Asparagine plays a vital role in the development of peptide-based therapeutics and drug discovery research. Its usage facilitates the creation of diverse peptide libraries, enabling researchers to explore structure-activity relationships and identify potential drug candidates.

Chemical Biology: BOC-D-Asparagine finds application in various chemical biology studies, including protein engineering, enzymatic assays, and peptide-protein interactions. Its ability to protect the amino group allows for controlled modifications and functionalization of peptides, facilitating the investigation of biological processes and molecular recognition.

Market Outlook: The demand for BOC-D-Asparagine is steadily growing within the peptide synthesis market due to its reliable performance and compatibility with various synthesis methods. The pharmaceutical industry, academic research laboratories, and contract manufacturing organizations (CMOs) heavily rely on BOC-D-Asparagine for peptide synthesis projects. The global market for peptide-based therapeutics is also expanding, driving the need for high-quality amino acid protecting agents.

Conclusion: BOC-D-Asparagine is a leading amino acid protecting agent utilized in peptide synthesis. Its excellent purity, effective amine protection, and stability make it an indispensable tool for chemists and researchers involved in peptide-based studies. With its wide range of applications in peptide synthesis, drug discovery, and chemical biology, BOC-D-Asparagine continues to contribute significantly to advancements in therapeutic development and molecular research.

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