BOC-D-Alanine
Nanjing Finechem Holdings Co., LTD
Specifications
N/A
Packing & Storage
Packing
Storage Powder -20°C 3 years 4°C 2 years;In solvent -80°C 6 months, -20°C 1 month
Shipping Room temperature in continental US; may vary elsewhere
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General Information
Chemical & Physical Properties
Safety Information
Synthetic Route
Biological Activity
Common Names Boc-D-Ala-OH
Structure
CAS No. 7764-95-6 Boiling Point (℃) 320.9±25.0 °C at 760 mmHg
Molecular Weight 189.209 Melting Point (℃) 81-83ºC
Density 1.1±0.1 g/cm3 Vapor Specific Gravity N/A
Molecular Formula C8H15NO4 Flash Point (℃) 147.9±23.2 °C
Solubility N/A Autoignition Temperature (℃) N/A
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes T+:Very toxic
Safety Phrases S1-S28-S45
RIDADR NONH for all modes of transport
WGK Germany  3
SYMPTOMS PREVENTION FIRST AID
Inhalation Cough. Sore throat. Use local exhaust or breathing protection. Fresh air, rest.
Skin Redness. Burning sensation. Itching. Protective gloves. Remove contaminated clothes. Rinse and then wash skin with water and soap.
Eyes Redness. Pain. Wear safety goggles. First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.
Ingestion Abdominal pain. Nausea. Vomiting. Do not eat, drink, or smoke during work. Wash hands before eating. Rinse mouth. Induce vomiting (ONLY IN CONSCIOUS PERSONS!). Refer for medical attention.
Description N-tert-Butoxycarbonyl-D-alanine is an alanine derivative[1].
Target Km: 100-400 μM (amino acid transporter b0,+)[1]
In Vitro Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1].
References [1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1092.
Synonyms
N-(tert-Butyloxycarbonyl)-l-alanine
(R)-2-tert-butoxycarbonylamino-propionic acid
BOC-D-Alanine
N-{[(2-Methyl-2-propanyl)oxy]carbonyl}-D-alanine
(R)-2-((tert-Butoxycarbonyl)amino)propanoic acid
(2S)-2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid
N-(tert-Butoxycarbonyl)-L-alanine
N-(tert-butyloxycarbonyl)-D-alanine
N-(tert-Butoxycarbonyl)alanine
N-tert-butyloxycarbonyl-(S)-alanine
(R)-N-(tert-butoxycarbonyl)alanine
N-(tert-Butoxycarbonyl)-D-alanine
N-Boc-D-alanine
(2R)-2-({[(2-Methyl-2-propanyl)oxy]carbonyl}amino)propanoic acid
Product Description
Introduction: BOC-D-Alanine is a versatile amino acid protecting agent widely used in peptide synthesis. Derived from alanine, BOC-D-Alanine plays a crucial role in protecting amino groups during the assembly of peptide chains. Known for its exceptional quality and reliability, BOC-D-Alanine has become a preferred choice among chemists and researchers involved in peptide synthesis.

Product Features: High Purity: BOC-D-Alanine is meticulously synthesized to ensure the highest level of purity, surpassing industry standards. Its exceptional purity guarantees minimal impurities, ensuring superior quality results and the synthesis of high-quality peptides.

Effective Amine Protection: BOC-D-Alanine acts as an efficient shield for amino groups, preventing undesired side reactions during peptide synthesis. By selectively protecting the amino group, it enables controlled and precise incorporation of amino acids into the growing peptide chain.

Compatibility with Various Synthesis Methods: BOC-D-Alanine exhibits excellent compatibility with a wide range of peptide synthesis methods, including both solution-phase and solid-phase synthesis. Its versatility allows chemists to utilize diverse strategies in peptide assembly.

Applications: Peptide Synthesis: BOC-D-Alanine is an essential component in solid-phase peptide synthesis (SPPS), the most widely used method for efficient peptide assembly. Its role as an amino acid protecting agent enables the stepwise addition of amino acids, preserving the integrity and controlled growth of the peptide chain.

Drug Development: BOC-D-Alanine finds extensive application in the pharmaceutical industry for the synthesis of peptide-based drugs and drug candidates. It allows for the creation of complex peptide sequences, facilitating the development of therapeutic peptides, peptide conjugates, and peptide mimetics.

Peptide Library Synthesis: BOC-D-Alanine is instrumental in the synthesis of peptide libraries, enabling the rapid exploration of structure-activity relationships and the identification of bioactive peptides. These libraries serve as valuable tools in drug discovery, molecular biology, and biotechnological research.

Market Outlook: The demand for BOC-D-Alanine is experiencing steady growth within the peptide synthesis market due to its reliable performance and compatibility with various synthesis methods. Pharmaceutical companies, academic research institutions, and contract manufacturing organizations (CMOs) heavily rely on BOC-D-Alanine for their peptide synthesis projects. With the increasing interest in peptide-based drugs and the continuous advancement of peptide therapeutics, there is a growing market for high-quality amino acid protecting agents.

Conclusion: BOC-D-Alanine stands as a versatile amino acid protecting agent in peptide synthesis. Its high purity, effective amine protection, and compatibility with various synthesis methods make it an indispensable tool for chemists and researchers involved in peptide-based studies. With its wide range of applications in peptide synthesis, drug development, and peptide library synthesis, BOC-D-Alanine continues to contribute to advancements in drug discovery, molecular biology, and therapeutic peptide research.

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